On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Nenad Bogdanovic, Lionel Bretillon, Erik G. Lund, Ulf Diczfalusy, Lars Lannfelt, Bengt Winblad, David W. Russell, Ingemar Björkhem

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Volume314
Issue number1-2
DOIs
StatePublished - Nov 13 2001

Fingerprint

Neuroglia
Alzheimer Disease
Cholesterol
Brain
Amyloidogenic Proteins
Brain Diseases
Cytochrome P450 Family 46
Staining and Labeling

Keywords

  • Alzheimer's disease
  • Cerebral cholesterol
  • Cholesterol 24S-hydroxylase
  • Cytochrome P-450
  • Oxysterols

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. / Bogdanovic, Nenad; Bretillon, Lionel; Lund, Erik G.; Diczfalusy, Ulf; Lannfelt, Lars; Winblad, Bengt; Russell, David W.; Björkhem, Ingemar.

In: Neuroscience Letters, Vol. 314, No. 1-2, 13.11.2001, p. 45-48.

Research output: Contribution to journalArticle

Bogdanovic, Nenad ; Bretillon, Lionel ; Lund, Erik G. ; Diczfalusy, Ulf ; Lannfelt, Lars ; Winblad, Bengt ; Russell, David W. ; Björkhem, Ingemar. / On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. In: Neuroscience Letters. 2001 ; Vol. 314, No. 1-2. pp. 45-48.
@article{fb72616fef284dd98a652d9e19d841a5,
title = "On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells",
abstract = "Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.",
keywords = "Alzheimer's disease, Cerebral cholesterol, Cholesterol 24S-hydroxylase, Cytochrome P-450, Oxysterols",
author = "Nenad Bogdanovic and Lionel Bretillon and Lund, {Erik G.} and Ulf Diczfalusy and Lars Lannfelt and Bengt Winblad and Russell, {David W.} and Ingemar Bj{\"o}rkhem",
year = "2001",
month = "11",
day = "13",
doi = "10.1016/S0304-3940(01)02277-7",
language = "English (US)",
volume = "314",
pages = "45--48",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

AU - Bogdanovic, Nenad

AU - Bretillon, Lionel

AU - Lund, Erik G.

AU - Diczfalusy, Ulf

AU - Lannfelt, Lars

AU - Winblad, Bengt

AU - Russell, David W.

AU - Björkhem, Ingemar

PY - 2001/11/13

Y1 - 2001/11/13

N2 - Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.

AB - Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol efflux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid β-protein in AD.

KW - Alzheimer's disease

KW - Cerebral cholesterol

KW - Cholesterol 24S-hydroxylase

KW - Cytochrome P-450

KW - Oxysterols

UR - http://www.scopus.com/inward/record.url?scp=0035856407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035856407&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(01)02277-7

DO - 10.1016/S0304-3940(01)02277-7

M3 - Article

C2 - 11698143

AN - SCOPUS:0035856407

VL - 314

SP - 45

EP - 48

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -