Once daily cefadroxil versus twice-daily cefaclor treatment of acute urinary tract infections in children

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Seventy-four infants and children (ages 1 month to 16 years) were treated with either 30 mg/kg of cefadroxil once a day or 15 mg/kg of cefaclor twice a day for 10 days. The patients were followed up with urine cultures at 2-5, 12-15 and 24-30 days after completion of therapy. Thirty-six received cefadroxil and 38 cefaclor and each group were well matched with regard to age, sex and temperature. Eighty-nine per cent of infection pathogens were Escherichia coli. The rates of recurrence after treatment were similar for each treatment group (cefadroxil 13.9%, cefaclor 10.5%). The once daily dosing of cefadroxil was considered an advantage in assuring patient compliance.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue numberSuppl. B
Publication statusPublished - 1982


ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

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