Oncogenic γ Herpesviruses EBV and HHV8 in Kidney Transplantation

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. EBV is associated with post-transplantation lymphoproliferative disorder (PTLD), with increased risk in EBV-seronegative patients on intensified immunosuppression. Human herpesvirus-8 is associated with Kaposi's sarcoma (KS), with an increased risk in certain patient populations. Diagnosis of PTLD and KS relies on tissue biopsy. The mainstay of therapy for both PTLD and Kaposi's sarcoma is a reduction of immunosuppression, and in the case of PTLD, consideration of rituximab. Chemotherapy, radiation therapy, or surgery is provided for disseminated or recalcitrant disease. The prognoses vary depending on the type of malignancy identified and stage of disease.

Original languageEnglish (US)
Pages (from-to)362-371
Number of pages10
JournalSeminars in Nephrology
Volume36
Issue number5
DOIs
StatePublished - Sep 1 2016

Keywords

  • Epstein-Barr virus
  • HHV-8
  • Kaposi's sarcoma
  • post-transplant lymphoproliferative disorder

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Oncogenic γ Herpesviruses EBV and HHV8 in Kidney Transplantation'. Together they form a unique fingerprint.

  • Cite this