Oncogenic ABl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

Zonghan Dai, Robert C. Quackenbush, Kevin D. Courtney, Matthew Grove, David Cortez, Gary W. Reuther, Ann Marie Pendergast

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Oncogenic forms of the Abl and Src tyrosine kinases trigger the destruction of the Abi proteins, a family of Abl-interacting proteins that antagonize the oncogenic potential of Abl after overexpression in fibroblasts. The destruction of the Abi proteins requires tyrosine kinase activity and is dependent on the ubiquitin-proteasome pathway. We show that degradation of the Abi proteins occurs through a Ras-independent pathway. Significantly, expression of the Abi proteins is lost in cell lines and bone marrow cells isolated from patients with aggressive Bcr-Abl-positive leukemias. These findings suggest that loss of Abi proteins may be a component in the progression of Bcr-Abl-positive leukemias and identify a novel pathway linking activated nonreceptor protein tyrosine kinases to the destruction of specific target proteins through the ubiquitinproteasome pathway.

Original languageEnglish (US)
Pages (from-to)1415-1424
Number of pages10
JournalGenes and Development
Volume12
Issue number10
StatePublished - May 15 1998

Fingerprint

src-Family Kinases
Ubiquitin
Proteolysis
Proteins
Protein-Tyrosine Kinases
Leukemia
Proteasome Endopeptidase Complex
Bone Marrow Cells
Fibroblasts
Cell Line

Keywords

  • Abi
  • Bcr-Abl
  • Ph-positive leukemia
  • Ubiquitin-dependent proteolysis
  • V-Src

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Dai, Z., Quackenbush, R. C., Courtney, K. D., Grove, M., Cortez, D., Reuther, G. W., & Pendergast, A. M. (1998). Oncogenic ABl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes and Development, 12(10), 1415-1424.

Oncogenic ABl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. / Dai, Zonghan; Quackenbush, Robert C.; Courtney, Kevin D.; Grove, Matthew; Cortez, David; Reuther, Gary W.; Pendergast, Ann Marie.

In: Genes and Development, Vol. 12, No. 10, 15.05.1998, p. 1415-1424.

Research output: Contribution to journalArticle

Dai, Z, Quackenbush, RC, Courtney, KD, Grove, M, Cortez, D, Reuther, GW & Pendergast, AM 1998, 'Oncogenic ABl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway', Genes and Development, vol. 12, no. 10, pp. 1415-1424.
Dai, Zonghan ; Quackenbush, Robert C. ; Courtney, Kevin D. ; Grove, Matthew ; Cortez, David ; Reuther, Gary W. ; Pendergast, Ann Marie. / Oncogenic ABl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. In: Genes and Development. 1998 ; Vol. 12, No. 10. pp. 1415-1424.
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