Online adaptive replanning method for prostate radiotherapy

Ergun E. Ahunbay, Cheng Peng, Shannon Holmes, Andrew Godley, Colleen Lawton, X. Allen Li

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Purpose: To report the application of an adaptive replanning technique for prostate cancer radiotherapy (RT), consisting of two steps: (1) segment aperture morphing (SAM), and (2) segment weight optimization (SWO), to account for interfraction variations. Methods and Materials: The new "SAM+SWO" scheme was retroactively applied to the daily CT images acquired for 10 prostate cancer patients on a linear accelerator and CT-on-Rails combination during the course of RT. Doses generated by the SAM+SWO scheme based on the daily CT images were compared with doses generated after patient repositioning using the current planning target volume (PTV) margin (5 mm, 3 mm toward rectum) and a reduced margin (2 mm), along with full reoptimization scans based on the daily CT images to evaluate dosimetry benefits. Results: For all cases studied, the online replanning method provided significantly better target coverage when compared with repositioning with reduced PTV (13% increase in minimum prostate dose) and improved organ sparing when compared with repositioning with regular PTV (13% decrease in the generalized equivalent uniform dose of rectum). The time required to complete the online replanning process was 6 ± 2 minutes. Conclusion: The proposed online replanning method can be used to account for interfraction variations for prostate RT with a practically acceptable time frame (5-10 min) and with significant dosimetric benefits. On the basis of this study, the developed online replanning scheme is being implemented in the clinic for prostate RT.

Original languageEnglish (US)
Pages (from-to)1561-1572
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume77
Issue number5
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Fingerprint

Prostate
radiation therapy
Radiotherapy
Rectum
Weights and Measures
planning
rectum
dosage
Prostatic Neoplasms
apertures
Moving and Lifting Patients
Particle Accelerators
optimization
margins
cancer
rails
linear accelerators
organs
dosimeters

Keywords

  • Adaptive radiotherapy
  • Image-guided radiotherapy
  • Online replanning
  • Prostate cancer

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Online adaptive replanning method for prostate radiotherapy. / Ahunbay, Ergun E.; Peng, Cheng; Holmes, Shannon; Godley, Andrew; Lawton, Colleen; Li, X. Allen.

In: International Journal of Radiation Oncology Biology Physics, Vol. 77, No. 5, 01.08.2010, p. 1561-1572.

Research output: Contribution to journalArticle

Ahunbay, Ergun E. ; Peng, Cheng ; Holmes, Shannon ; Godley, Andrew ; Lawton, Colleen ; Li, X. Allen. / Online adaptive replanning method for prostate radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2010 ; Vol. 77, No. 5. pp. 1561-1572.
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