Operative treatment of acute hip fractures: Its effect on serum creatine kinase, lactate dehydrogenase and their isoenzymes

Dane K. Wukich, John J. Callaghan, Geoffrey M. Graeber, Thomas Martyak, Jonathan J. Lyon

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Serum creatine kinase, lactate dehydrogenase, and their isoenzymes were prospectively studied in 16 patients who underwent operative treatment of acute hip fractures. No perioperative myocardial infarctions occurred; however, two patients died of noncardiac causes. We found that skeletal muscle injury associated with operative treatment of acute hip fractures did not result in significant elevations of serum CK-MB or the LD-l/LD-2 ratio. CK-MB activity exceeding 5% of total CK activity was observed in five patients who did not experience acute perioperative myocardial infarction; however, no patient had an absolute CK-MB value exceeding 50 IU/L. Elevations of serum CK-MB exceeding 50 IU/L and a LD-l/LD-2 ratio exceeding 1.0, therefore, should not be attributed to skeletal muscle injury alone following the operative treatment of acute hip fractures.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number3
StatePublished - Mar 1989


ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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