TY - JOUR
T1 - Opposite effects of coinjection and distant injection of mesenchymal stem cells on breast tumor cell growth
AU - Zheng, Huilin
AU - Zou, Weibin
AU - Shen, Jiaying
AU - Xu, Liang
AU - Wang, Shu
AU - Fu, Yang Xin
AU - Fan, Weimin
N1 - Publisher Copyright:
© AlphaMed Press 2016.
PY - 2016
Y1 - 2016
N2 - Mesenchymal stem cells (MSCs) usually promote tumor growth and metastasis. By using a breast tumor 4T1 cell-based animal model, this study determined that coinjection and distant injection of allogeneic bone marrow-derived MSCs with tumor cells could exert different effects on tumor growth. Whereas the coinjection of MSCs with 4T1 cells promoted tumor growth, surprisingly, the injection of MSCs at a site distant from the 4T1 cell inoculation site suppressed tumor growth. We further observed that, in the distant injection model, MSCs decreased the accumulation of myeloid-derived suppressor cells and regulatory T cells in tumor tissues by enhancing proinflammatory factors such as interferon-ɤ, tumor necrosis factor-α, Toll-like receptor (TLR)-3, and TLR-4, promoting host antitumor immunity and inhibiting tumor growth. Unlike previous reports, this is the first study reporting that MSCs may exert opposite roles on tumor growth in the same animal model by modulating the host immune system, which may shed light on the potential application of MSCs as vehicles for tumor therapy and other clinical applications.
AB - Mesenchymal stem cells (MSCs) usually promote tumor growth and metastasis. By using a breast tumor 4T1 cell-based animal model, this study determined that coinjection and distant injection of allogeneic bone marrow-derived MSCs with tumor cells could exert different effects on tumor growth. Whereas the coinjection of MSCs with 4T1 cells promoted tumor growth, surprisingly, the injection of MSCs at a site distant from the 4T1 cell inoculation site suppressed tumor growth. We further observed that, in the distant injection model, MSCs decreased the accumulation of myeloid-derived suppressor cells and regulatory T cells in tumor tissues by enhancing proinflammatory factors such as interferon-ɤ, tumor necrosis factor-α, Toll-like receptor (TLR)-3, and TLR-4, promoting host antitumor immunity and inhibiting tumor growth. Unlike previous reports, this is the first study reporting that MSCs may exert opposite roles on tumor growth in the same animal model by modulating the host immune system, which may shed light on the potential application of MSCs as vehicles for tumor therapy and other clinical applications.
KW - Breast tumor
KW - Coinjection
KW - Distant injection
KW - Immunomodulatory
KW - Mesenchymal stem cell
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U2 - 10.5966/sctm.2015-0300
DO - 10.5966/sctm.2015-0300
M3 - Article
C2 - 27352928
AN - SCOPUS:84983379959
SN - 2157-6564
VL - 5
SP - 1216
EP - 1228
JO - Stem Cells Translational Medicine
JF - Stem Cells Translational Medicine
IS - 9
ER -