Opposite effects of coinjection and distant injection of mesenchymal stem cells on breast tumor cell growth

Huilin Zheng, Weibin Zou, Jiaying Shen, Liang Xu, Shu Wang, Yang Xin Fu, Weimin Fan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) usually promote tumor growth and metastasis. By using a breast tumor 4T1 cell-based animal model, this study determined that coinjection and distant injection of allogeneic bone marrow-derived MSCs with tumor cells could exert different effects on tumor growth. Whereas the coinjection of MSCs with 4T1 cells promoted tumor growth, surprisingly, the injection of MSCs at a site distant from the 4T1 cell inoculation site suppressed tumor growth. We further observed that, in the distant injection model, MSCs decreased the accumulation of myeloid-derived suppressor cells and regulatory T cells in tumor tissues by enhancing proinflammatory factors such as interferon-ɤ, tumor necrosis factor-α, Toll-like receptor (TLR)-3, and TLR-4, promoting host antitumor immunity and inhibiting tumor growth. Unlike previous reports, this is the first study reporting that MSCs may exert opposite roles on tumor growth in the same animal model by modulating the host immune system, which may shed light on the potential application of MSCs as vehicles for tumor therapy and other clinical applications.

Original languageEnglish (US)
Pages (from-to)1216-1228
Number of pages13
JournalStem cells translational medicine
Volume5
Issue number9
DOIs
StatePublished - Jan 1 2016

Fingerprint

Mesenchymal Stromal Cells
Breast Neoplasms
Injections
Growth
Neoplasms
Animal Models
Toll-Like Receptor 3
Toll-Like Receptor 4
Regulatory T-Lymphocytes
Interferons
Immune System
Immunity
Tumor Necrosis Factor-alpha
Bone Marrow
Neoplasm Metastasis

Keywords

  • Breast tumor
  • Coinjection
  • Distant injection
  • Immunomodulatory
  • Mesenchymal stem cell

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Opposite effects of coinjection and distant injection of mesenchymal stem cells on breast tumor cell growth. / Zheng, Huilin; Zou, Weibin; Shen, Jiaying; Xu, Liang; Wang, Shu; Fu, Yang Xin; Fan, Weimin.

In: Stem cells translational medicine, Vol. 5, No. 9, 01.01.2016, p. 1216-1228.

Research output: Contribution to journalArticle

Zheng, Huilin ; Zou, Weibin ; Shen, Jiaying ; Xu, Liang ; Wang, Shu ; Fu, Yang Xin ; Fan, Weimin. / Opposite effects of coinjection and distant injection of mesenchymal stem cells on breast tumor cell growth. In: Stem cells translational medicine. 2016 ; Vol. 5, No. 9. pp. 1216-1228.
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