Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists

D. W. Self, W. J. Barnhart, D. A. Lehman, E. J. Nestler

Research output: Contribution to journalArticle

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Abstract

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior, We found that this 'priming' effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior, These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

Original languageEnglish (US)
Pages (from-to)1586-1589
Number of pages4
JournalScience
Volume271
Issue number5255
DOIs
StatePublished - Jan 1 1996

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