Optic nerve head component responses of the multifocal electroretinogram in MS

Teresa C. Frohman, Shin C Beh, Shiv Saidha, Zane Schnurman, Darrel Conger, Amy Conger, John N. Ratchford, Carmen Lopez, Steven L. Galetta, Peter A. Calabresi, Laura J. Balcer, Ari J. Green, Elliot Frohman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objective: To employ a novel stimulation paradigm in order to elicit multifocal electroretinography (mfERG)?induced optic nerve head component (ONHC) responses, believed to be contingent upon the transformation in electrical transmission properties of retinal ganglion cell axons from membrane to saltatory conduction mechanisms, as they traverse the lamina cribrosa and obtain oligodendrocyte myelin. We further sought to characterize abnormalities in ONHC responses in eyes from patients with multiple sclerosis (MS). Methods: In 10 normal subjects and 7 patients with MS (including eyes with and without a history of acute optic neuritis), we utilized a novel mfERG stimulation paradigm that included interleaved global flashes in order to elicit the ONHC responses from 103 retinal patches of pattern-reversal stimulation. Results: The number of abnormal or absent ONHC responses was significantly increased in MS patient eyes compared to normal subject eyes (p , 0.001, by general estimating equation modeling, and accounting for age and within-subject, intereye correlations). Conclusion: Studying the relationship between ONHC abnormalities and alterations in validated structural and functional measures of the visual system may facilitate the ability to dissect and characterize the pathobiological mechanisms that contribute to tissue damage in MS, and may have utility to detect and monitor neuroprotective or restorative effects of novel therapies.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalNeurology
Volume81
Issue number6
DOIs
StatePublished - Aug 6 2013

ASJC Scopus subject areas

  • Clinical Neurology

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    Frohman, T. C., Beh, S. C., Saidha, S., Schnurman, Z., Conger, D., Conger, A., Ratchford, J. N., Lopez, C., Galetta, S. L., Calabresi, P. A., Balcer, L. J., Green, A. J., & Frohman, E. (2013). Optic nerve head component responses of the multifocal electroretinogram in MS. Neurology, 81(6), 545-551. https://doi.org/10.1212/WNL.0b013e31829e6faa