Optic neuritis: A mechanistic view

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Acute demyelinating optic neuritis is a condition of the optic nerves characterized by inflammation, demyelination, and neurodegeneration. Optic neuritis is a relatively common demyelinating event, strongly associated with multiple sclerosis. A number of clinical, radiographic, retinal imaging, and electrophysiologic techniques have provided significant insight into the pathologic and pathophysiologic mechanisms of optic neuritis and its related disorder multiple sclerosis. The development of validated biomarkers within the anterior visual system has paved the way for novel investigations aimed at characterizing the processes of axonal loss and neurodegeneration, neuroprotection, and perhaps even neurorestoration strategies.

Original languageEnglish (US)
Pages (from-to)81-92
Number of pages12
Issue number1
StatePublished - Feb 2011


  • Macular volume
  • Multiple sclerosis
  • Optic neuritis
  • Optical coherence tomography pupil light reflex
  • Retinal nerve fiber layer
  • Visual evoked potentials

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Physiology (medical)


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