Optical enhancement of DNA-base radio-resistivity

Ramin M. Abolfath, Lech Papiez, Strahinja Stojadinovic, Timothy Solberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a mechanism which uses the simultaneous application of circularly polarized light and an external magnetic field to control the polarization of the free radicals and create S=1 electron-hole spin excitations (excitons) on nucleotide-base. We deploy an ab-initio molecular dynamics model to calculate the characteristic parameters of the light needed for optical transitions. The effect of spin-injection on the formation of a free energy barrier in diffusion controlled chemical reaction pathways leads to the control of radiation-induced base damage. The proposed method allows us to manipulate and partially suppress the damage induced by ionizing radiation.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationRadiation Protection and Dosimetry, Biological Effects of Radiation
Pages124-127
Number of pages4
Edition3
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Radiation Protection and Dosimetry, Biological Effects of Radiation - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number3
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Radiation Protection and Dosimetry, Biological Effects of Radiation
CountryGermany
CityMunich
Period9/7/099/12/09

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Keywords

  • DNA damage
  • Radiation protector

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Abolfath, R. M., Papiez, L., Stojadinovic, S., & Solberg, T. (2009). Optical enhancement of DNA-base radio-resistivity. In World Congress on Medical Physics and Biomedical Engineering: Radiation Protection and Dosimetry, Biological Effects of Radiation (3 ed., pp. 124-127). (IFMBE Proceedings; Vol. 25, No. 3). https://doi.org/10.1007/978-3-642-03902-7-36