Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice

Gabrielle S. Wong, Peiman Habibollahi, Pedram Heidari, Ju Seog Lee, Andres J. Klein-Szanto, Todd J. Waldron, Phyllis Gimotty, Hiroshi Nakagawa, Philip R. Taylor, Timothy C. Wang, Umar Mahmood, Anil K. Rustgi

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in preneoplastic and neoplastic esophageal lesions using near-infrared fluorescent imaging with upper-gastrointestinal endoscopy. Periostin might be a biomarker of the esophageal tumor microenvironment that can be used to detect preneoplastic lesions.

Original languageEnglish (US)
Pages (from-to)294-297
Number of pages4
JournalGastroenterology
Volume144
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Keywords

  • Esophageal cancer
  • Extracellular matrix
  • Mouse model
  • POSTN
  • Tumor microenvironment

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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  • Cite this

    Wong, G. S., Habibollahi, P., Heidari, P., Lee, J. S., Klein-Szanto, A. J., Waldron, T. J., Gimotty, P., Nakagawa, H., Taylor, P. R., Wang, T. C., Mahmood, U., & Rustgi, A. K. (2013). Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice. Gastroenterology, 144(2), 294-297. https://doi.org/10.1053/j.gastro.2012.10.030