Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice

Gabrielle S. Wong, Peiman Habibollahi, Pedram Heidari, Ju Seog Lee, Andres J. Klein-Szanto, Todd J. Waldron, Phyllis Gimotty, Hiroshi Nakagawa, Philip R. Taylor, Timothy C. Wang, Umar Mahmood, Anil K. Rustgi

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in preneoplastic and neoplastic esophageal lesions using near-infrared fluorescent imaging with upper-gastrointestinal endoscopy. Periostin might be a biomarker of the esophageal tumor microenvironment that can be used to detect preneoplastic lesions.

Original languageEnglish (US)
Pages (from-to)294-297
Number of pages4
JournalGastroenterology
Volume144
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Keywords

  • Esophageal cancer
  • Extracellular matrix
  • Mouse model
  • POSTN
  • Tumor microenvironment

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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