TY - JOUR
T1 - Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy
AU - Busch, David R.
AU - Choe, Regine
AU - Rosen, Mark A.
AU - Guo, Wensheng
AU - Durduran, Turgut
AU - Feldman, Michael D.
AU - Mies, Carolyn
AU - Czerniecki, Brian J.
AU - Tchou, Julia
AU - DeMichele, Angela
AU - Schnall, Mitchell D.
AU - Yodh, Arjun G.
PY - 2013
Y1 - 2013
N2 - We introduce and demonstrate use of a novel, diffuse optical tomography (DOT) based breast cancer signature for monitoring progression of neoadjuvant chemotherapy. This signature, called probability of malignancy, is obtained by statistical image analysis of total hemoglobin concentration, blood oxygen saturation, and scattering coefficient distributions in the breast tomograms of a training-set population with biopsy-confirmed breast cancers. A pilot clinical investigation adapts this statistical image analysis approach for chemotherapy monitoring of three patients. Though preliminary, the study shows how to use the malignancy parameter for separating responders from partial-responders and demonstrates the potential utility of the methodology compared to traditional DOT quantification schemes.
AB - We introduce and demonstrate use of a novel, diffuse optical tomography (DOT) based breast cancer signature for monitoring progression of neoadjuvant chemotherapy. This signature, called probability of malignancy, is obtained by statistical image analysis of total hemoglobin concentration, blood oxygen saturation, and scattering coefficient distributions in the breast tomograms of a training-set population with biopsy-confirmed breast cancers. A pilot clinical investigation adapts this statistical image analysis approach for chemotherapy monitoring of three patients. Though preliminary, the study shows how to use the malignancy parameter for separating responders from partial-responders and demonstrates the potential utility of the methodology compared to traditional DOT quantification schemes.
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U2 - 10.1364/BOE.4.000105
DO - 10.1364/BOE.4.000105
M3 - Article
C2 - 23304651
AN - SCOPUS:84871786865
SN - 2156-7085
VL - 4
SP - 105
EP - 121
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 1
ER -