Optical monitoring and detection of spinal cord ischemia

Rickson C. Mesquita, Angela D'Souza, Thomas V. Bilfinger, Robert M. Galler, Asher Emanuel, Steven S. Schenkel, Arjun G. Yodh, Thomas F. Floyd

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Spinal cord ischemia can lead to paralysis or paraparesis, but if detected early it may be amenable to treatment. Current methods use evoked potentials for detection of spinal cord ischemia, a decades old technology whose warning signs are indirect and significantly delayed from the onset of ischemia. Here we introduce and demonstrate a prototype fiber optic device that directly measures spinal cord blood flow and oxygenation. This technical advance in neurological monitoring promises a new standard of care for detection of spinal cord ischemia and the opportunity for early intervention. We demonstrate the probe in an adult Dorset sheep model. Both open and percutaneous approaches were evaluated during pharmacologic, physiological, and mechanical interventions designed to induce variations in spinal cord blood flow and oxygenation. The induced variations were rapidly and reproducibly detected, demonstrating direct measurement of spinal cord ischemia in real-time. In the future, this form of hemodynamic spinal cord diagnosis could significantly improve monitoring and management in a broad range of patients, including those undergoing thoracic and abdominal aortic revascularization, spine stabilization procedures for scoliosis and trauma, spinal cord tumor resection, and those requiring management of spinal cord injury in intensive care settings.

Original languageEnglish (US)
Article numbere83370
JournalPLoS One
Volume8
Issue number12
DOIs
StatePublished - Dec 16 2013

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Spinal Cord Ischemia
ischemia
spinal cord
Spinal Cord
Monitoring
monitoring
Fetal Blood
Spinal Cord Neoplasms
Paraparesis
Scoliosis
Oxygenation
Critical Care
Standard of Care
Spinal Cord Injuries
Evoked Potentials
Paralysis
Sheep
blood flow
Spine
Thorax

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Mesquita, R. C., D'Souza, A., Bilfinger, T. V., Galler, R. M., Emanuel, A., Schenkel, S. S., ... Floyd, T. F. (2013). Optical monitoring and detection of spinal cord ischemia. PLoS One, 8(12), [e83370]. https://doi.org/10.1371/journal.pone.0083370

Optical monitoring and detection of spinal cord ischemia. / Mesquita, Rickson C.; D'Souza, Angela; Bilfinger, Thomas V.; Galler, Robert M.; Emanuel, Asher; Schenkel, Steven S.; Yodh, Arjun G.; Floyd, Thomas F.

In: PLoS One, Vol. 8, No. 12, e83370, 16.12.2013.

Research output: Contribution to journalArticle

Mesquita, RC, D'Souza, A, Bilfinger, TV, Galler, RM, Emanuel, A, Schenkel, SS, Yodh, AG & Floyd, TF 2013, 'Optical monitoring and detection of spinal cord ischemia', PLoS One, vol. 8, no. 12, e83370. https://doi.org/10.1371/journal.pone.0083370
Mesquita RC, D'Souza A, Bilfinger TV, Galler RM, Emanuel A, Schenkel SS et al. Optical monitoring and detection of spinal cord ischemia. PLoS One. 2013 Dec 16;8(12). e83370. https://doi.org/10.1371/journal.pone.0083370
Mesquita, Rickson C. ; D'Souza, Angela ; Bilfinger, Thomas V. ; Galler, Robert M. ; Emanuel, Asher ; Schenkel, Steven S. ; Yodh, Arjun G. ; Floyd, Thomas F. / Optical monitoring and detection of spinal cord ischemia. In: PLoS One. 2013 ; Vol. 8, No. 12.
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