Optically measured microvascular blood flow contrast of malignant breast tumors

Regine Choe, Mary E. Putt, Peter M. Carlile, Turgut Durduran, Joseph M. Giammarco, David R. Busch, Ki Won Jung, Brian J. Czerniecki, Julia Tchou, Michael D. Feldman, Carolyn Mies, Mark A. Rosen, Mitchell D. Schnall, Angela DeMichele, Arjun G. Yodh

Research output: Contribution to journalArticle

Abstract

Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geometry. The probe employs diffuse correlation spectroscopy (DCS), a near-infrared optical method that quantifies deep tissue microvascular blood flow. Tumor-to-normal perfusion ratios are derived from thirty-two human subjects. Mean (95% confidence interval) tumor-to-normal ratio using surrounding normal tissue was 2.25 (1.92-2.63); tumor-to-normal ratio using normal tissues at the corresponding tumor location in the contralateral breast was 2.27 (1.94-2.66), and using normal tissue in the contralateral breast was 2.27 (1.90-2.70). Thus, the mean tumor-to-normal ratios were significantly different from unity irrespective of the normal tissue chosen, implying that tumors have significantly higher blood flow than normal tissues. Therefore, the study demonstrates existence of breast cancer contrast in blood flow measured by DCS. The new, optically accessible cancer contrast holds potential for cancer detection and therapy monitoring applications, and it is likely to be especially useful when combined with diffuse optical spectroscopy/tomography.

Original languageEnglish (US)
Article numbere99683
JournalPloS one
Volume9
Issue number6
DOIs
StatePublished - Jun 26 2014
Externally publishedYes

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middle-aged adults
Laser-Doppler Flowmetry
Regional Blood Flow
Microvessels
case-control studies
breast neoplasms
blood flow
Case-Control Studies
Breast Neoplasms
neoplasms
Neoplasms
breasts
spectroscopy
Spectrum Analysis
Breast
Optical Tomography
therapeutics
Near-Infrared Spectroscopy
monitoring
tomography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Choe, R., Putt, M. E., Carlile, P. M., Durduran, T., Giammarco, J. M., Busch, D. R., ... Yodh, A. G. (2014). Optically measured microvascular blood flow contrast of malignant breast tumors. PloS one, 9(6), [e99683]. https://doi.org/10.1371/journal.pone.0099683

Optically measured microvascular blood flow contrast of malignant breast tumors. / Choe, Regine; Putt, Mary E.; Carlile, Peter M.; Durduran, Turgut; Giammarco, Joseph M.; Busch, David R.; Jung, Ki Won; Czerniecki, Brian J.; Tchou, Julia; Feldman, Michael D.; Mies, Carolyn; Rosen, Mark A.; Schnall, Mitchell D.; DeMichele, Angela; Yodh, Arjun G.

In: PloS one, Vol. 9, No. 6, e99683, 26.06.2014.

Research output: Contribution to journalArticle

Choe, R, Putt, ME, Carlile, PM, Durduran, T, Giammarco, JM, Busch, DR, Jung, KW, Czerniecki, BJ, Tchou, J, Feldman, MD, Mies, C, Rosen, MA, Schnall, MD, DeMichele, A & Yodh, AG 2014, 'Optically measured microvascular blood flow contrast of malignant breast tumors', PloS one, vol. 9, no. 6, e99683. https://doi.org/10.1371/journal.pone.0099683
Choe, Regine ; Putt, Mary E. ; Carlile, Peter M. ; Durduran, Turgut ; Giammarco, Joseph M. ; Busch, David R. ; Jung, Ki Won ; Czerniecki, Brian J. ; Tchou, Julia ; Feldman, Michael D. ; Mies, Carolyn ; Rosen, Mark A. ; Schnall, Mitchell D. ; DeMichele, Angela ; Yodh, Arjun G. / Optically measured microvascular blood flow contrast of malignant breast tumors. In: PloS one. 2014 ; Vol. 9, No. 6.
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