Optimizing individual nutrition in preterm very low birth weight infants: double-blinded randomized controlled trial

Luc P. Brion, Charles R. Rosenfeld, Roy Heyne, L. Steven Brown, Cheryl S. Lair, Elen Petrosyan, Theresa Jacob, Maria Caraig, Patti J. Burchfield

Research output: Contribution to journalArticle

Abstract

Objective: In preterm neonates fed human milk, fortification may be adjusted by (1) optimization, based on growth rate and serum nutrient analyses, or (2) individualization, based on serial milk nutrient analyses. The primary aim was to determine whether individualized plus optimized nutrition (experimental) improves velocity of weight gain and linear growth from birth to endpoint (36 weeks postmenstrual age or discharge) when compared with optimized nutrition alone (controls). Study design: Double-blinded parallel group randomized trial in 120 neonates <29 weeks gestational age (GA) or <35 weeks and small for GA (birth weight < 10th centile). Result: Weight-gain velocity (13.1 ± 2.1, n = 57 controls, vs. 13.0 ± 2.6 g kg−1 day−1, n = 59 experimental, P = 0.87), linear growth (0.9 ± 0.2, n = 55, vs. 0.9 ± 0.2 cm week−1, n = 52, P = 0.90) and frequency of weight/length disproportion (2% vs. 2%, P = 0.98) were similar in both groups. Conclusions: Individualized plus optimized nutrition does not improve weight gain, linear growth, or weight/length disproportion at endpoint versus optimized nutrition alone.

Original languageEnglish (US)
Pages (from-to)655-665
Number of pages11
JournalJournal of Perinatology
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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