TY - JOUR
T1 - Optimizing oxygen therapy for preterm infants at birth
T2 - Are we there yet?
AU - Kapadia, Vishal
AU - Lee Oei, Ju
N1 - Funding Information:
Supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Institutes of Health grant 1K23HD083511-01A1 (to Dr Kapadia). Funded by the National Institutes of Health (NIH).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/4
Y1 - 2020/4
N2 - Premature infants undergo a complex postnatal adaptation at birth. For last two centuries, oxygen has been integral to respiratory support of preterm infants at birth. Excess oxygen can cause oxidative stress and tissue injury. Preterm infants due to lung immaturity may need oxygen for successful transition at birth. Although, considerable progress has been made in the last 3 decades, optimum oxygen therapy for preterm delivery room resuscitation remains unknown. In this review, we discuss the history and physiology behind oxygen therapy in the delivery room, evaluate current literature, provide practice points and point out knowledge gaps of oxygen therapy in preterm infant at birth.
AB - Premature infants undergo a complex postnatal adaptation at birth. For last two centuries, oxygen has been integral to respiratory support of preterm infants at birth. Excess oxygen can cause oxidative stress and tissue injury. Preterm infants due to lung immaturity may need oxygen for successful transition at birth. Although, considerable progress has been made in the last 3 decades, optimum oxygen therapy for preterm delivery room resuscitation remains unknown. In this review, we discuss the history and physiology behind oxygen therapy in the delivery room, evaluate current literature, provide practice points and point out knowledge gaps of oxygen therapy in preterm infant at birth.
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U2 - 10.1016/j.siny.2020.101081
DO - 10.1016/j.siny.2020.101081
M3 - Review article
C2 - 32044281
AN - SCOPUS:85079164015
SN - 1744-165X
VL - 25
JO - Seminars in Fetal and Neonatal Medicine
JF - Seminars in Fetal and Neonatal Medicine
IS - 2
M1 - 101081
ER -