TY - JOUR
T1 - Optimizing Therapeutic Effects in Patients with Comorbidities
T2 - Drug-Resistant Tremor, Autonomic Dysfunction, Psychiatric Disorders, and Cognitive Impairment
AU - Chitnis, Shilpa
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Parkinsonism is a syndrome characterized by a combination of cardinal features including resting tremor, bradykinesia, rigidity, and loss of postural reflexes. The most common presentation of parkinsonism is the idiopathic variety first described by James Parkinson in 1817 now known as Parkinson's disease (PD). This article focuses on identifying the different subtypes of PD, with the recognition that treatment approaches may differ depending on the initial presenting feature. It also addresses issues related to the recognition and treatment of nonmotor comorbidities of PD, such as autonomic dysfunction and neuropsychiatric problems including depression and dementia.
AB - Parkinsonism is a syndrome characterized by a combination of cardinal features including resting tremor, bradykinesia, rigidity, and loss of postural reflexes. The most common presentation of parkinsonism is the idiopathic variety first described by James Parkinson in 1817 now known as Parkinson's disease (PD). This article focuses on identifying the different subtypes of PD, with the recognition that treatment approaches may differ depending on the initial presenting feature. It also addresses issues related to the recognition and treatment of nonmotor comorbidities of PD, such as autonomic dysfunction and neuropsychiatric problems including depression and dementia.
UR - http://www.scopus.com/inward/record.url?scp=50649112387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50649112387&partnerID=8YFLogxK
U2 - 10.1016/j.ncl.2008.05.005
DO - 10.1016/j.ncl.2008.05.005
M3 - Review article
C2 - 18774441
AN - SCOPUS:50649112387
SN - 0733-8619
VL - 26
SP - 29
EP - 44
JO - Neurologic Clinics
JF - Neurologic Clinics
IS - 3 SUPPL.
ER -