Oral administration of somatostatin reduces postprandial plasma triglycerides, gastrin and gut glucagon-like immunoreactivity

V. Schusdziarra, D. Rouiller, Roger H Unger

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The present study was designed to determine if orally administered somatostatin can reduce the postprandial rise in plasma triglycerides, gastrin, gut glucagon-like immunoreactivity (GLI) and the pancreatic hormones insulin and glucagon. Ten overnight fasted dogs were fed a fat-protein meal with or without 2 mg synthetic somatostatin, followed by another 2 mg somatostatin 90 min later. After the meal with somatostatin, postprandial plasma triglyceride levels were significantly lower for 5 hours, GLI levels for 3.5 hours and gastrin levels for 1 hour compared to the controls. Plasma insulin, glucagon and somatostatin-like immunoreactivity was not different from the control experiments. It is concluded that orally administered somatostatin lowers the postprandial levels of triglycerides, GLI and gastrin in dogs. This may have therapeutic implications for the management of gastrointestinal and metabolic disorders.

Original languageEnglish (US)
Pages (from-to)1595-1600
Number of pages6
JournalLife Sciences
Volume24
Issue number17
DOIs
StatePublished - Apr 23 1979

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Glucagon-Like Peptides
Gastrins
Somatostatin
Oral Administration
Triglycerides
Plasmas
Meals
Pancreatic Hormones
Dogs
Insulin
Glucagon
Fats
glucagon-like-immunoreactivity
Proteins
Experiments

ASJC Scopus subject areas

  • Pharmacology

Cite this

Oral administration of somatostatin reduces postprandial plasma triglycerides, gastrin and gut glucagon-like immunoreactivity. / Schusdziarra, V.; Rouiller, D.; Unger, Roger H.

In: Life Sciences, Vol. 24, No. 17, 23.04.1979, p. 1595-1600.

Research output: Contribution to journalArticle

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