Oral clopidogrel load in aspirin-resistant capsular warning syndrome

Christopher D. Fahey, Mark J. Alberts, Richard A. Bernstein

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel. Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

Original languageEnglish (US)
Pages (from-to)183-184
Number of pages2
JournalNeurocritical Care
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2005

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Keywords

  • Acute brain ischemia
  • Antiplatelet therapy
  • Capsular warning syndrome
  • Ischemic stroke
  • Transient ischemic attack

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

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