Oral clopidogrel load in aspirin-resistant capsular warning syndrome

Christopher D. Fahey; Mark J. Alberts; Richard A. Bernstein

doi:10.1385/NCC:2:2:183

Oral clopidogrel load in aspirin-resistant capsular warning syndrome

Christopher D. Fahey, Mark J. Alberts, Richard A. Bernstein

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel. Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

Original language	English (US)
Pages (from-to)	183-184
Number of pages	2
Journal	Neurocritical Care
Volume	2
Issue number	2
DOIs	https://doi.org/10.1385/NCC:2:2:183
State	Published - Apr 2005

Keywords

Acute brain ischemia
Antiplatelet therapy
Capsular warning syndrome
Ischemic stroke
Transient ischemic attack

ASJC Scopus subject areas

Clinical Neurology
Critical Care and Intensive Care Medicine

Access to Document

10.1385/NCC:2:2:183

Cite this

@article{c270f86685504513aae1652152e43650,

title = "Oral clopidogrel load in aspirin-resistant capsular warning syndrome",

abstract = "Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel. Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.",

keywords = "Acute brain ischemia, Antiplatelet therapy, Capsular warning syndrome, Ischemic stroke, Transient ischemic attack",

author = "Fahey, {Christopher D.} and Alberts, {Mark J.} and Bernstein, {Richard A.}",

year = "2005",

month = apr,

doi = "10.1385/NCC:2:2:183",

language = "English (US)",

volume = "2",

pages = "183--184",

journal = "Neurocritical Care",

issn = "1541-6933",

publisher = "Humana Press",

number = "2",

}

TY - JOUR

T1 - Oral clopidogrel load in aspirin-resistant capsular warning syndrome

AU - Fahey, Christopher D.

AU - Alberts, Mark J.

AU - Bernstein, Richard A.

PY - 2005/4

Y1 - 2005/4

N2 - Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel. Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

AB - Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel. Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

KW - Acute brain ischemia

KW - Antiplatelet therapy

KW - Capsular warning syndrome

KW - Ischemic stroke

KW - Transient ischemic attack

UR - http://www.scopus.com/inward/record.url?scp=24644458858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644458858&partnerID=8YFLogxK

U2 - 10.1385/NCC:2:2:183

DO - 10.1385/NCC:2:2:183

M3 - Article

C2 - 16159063

AN - SCOPUS:24644458858

SN - 1541-6933

VL - 2

SP - 183

EP - 184

JO - Neurocritical Care

JF - Neurocritical Care

IS - 2

ER -

Oral clopidogrel load in aspirin-resistant capsular warning syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this