Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women

Ronee E. Harvey, Emma C. Hart, Nisha Charkoudian, Timothy B. Curry, Jason R. Carter, Qi Fu, Christopher T. Minson, Michael J. Joyner, Jill N. Barnes

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Endogenous female sex hormones influence muscle sympathetic nerve activity (MSNA), a regulator of arterial blood pressure and important factor in hypertension development. Although ≈80% of American women report using hormonal contraceptives sometime during their life, the influence of combined oral contraceptives (OCs) on MSNA and systemic hemodynamics remains equivocal. The goal of this study was to determine whether women taking OCs have altered MSNA and hemodynamics (cardiac output and total peripheral resistance) at rest during the placebo phase of OC use compared with women with natural menstrual cycles during the early follicular phase. We retrospectively analyzed data from studies in which healthy, premenopausal women (aged 18-35 years) participated. We collected MSNA values at rest and hemodynamic measurements in women taking OCs (n=53; 25±4 years) and women with natural menstrual cycles (n=74; 25±4 years). Blood pressure was higher in women taking OCs versus those with natural menstrual cycles (mean arterial pressure, 89±1 versus 85±1 mm Hg, respectively; P=0.01), although MSNA was similar in both groups (MSNA burst incidence, 16±1 versus 18±1 bursts/100 heartbeats, respectively; P=0.19). In a subset of women in which detailed hemodynamic data were available, those taking OCs (n=33) had similar cardiac output (4.9±0.2 versus 4.7±0.2 L/min, respectively; P=0.47) and total peripheral resistance (19.2±0.8 versus 20.0±0.9 U, respectively; P=0.51) as women with natural menstrual cycles (n=22). In conclusion, women taking OCs have higher resting blood pressure and similar MSNA and hemodynamics during the placebo phase of OC use when compared with naturally menstruating women in the early follicular phase.

Original languageEnglish (US)
Pages (from-to)590-597
Number of pages8
JournalHypertension
Volume66
Issue number3
DOIs
StatePublished - Sep 14 2015

Fingerprint

Oral Contraceptives
Hemodynamics
Muscles
Menstrual Cycle
Follicular Phase
Hypertension
Cardiac Output
Vascular Resistance
Arterial Pressure
Placebos
Contraceptives, Oral, Combined
Gonadal Steroid Hormones
Contraceptive Agents

Keywords

  • blood pressure
  • follicular phase
  • hemodynamics
  • hypertension
  • oral contraceptives

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Harvey, R. E., Hart, E. C., Charkoudian, N., Curry, T. B., Carter, J. R., Fu, Q., ... Barnes, J. N. (2015). Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women. Hypertension, 66(3), 590-597. https://doi.org/10.1161/HYPERTENSIONAHA.115.05179

Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women. / Harvey, Ronee E.; Hart, Emma C.; Charkoudian, Nisha; Curry, Timothy B.; Carter, Jason R.; Fu, Qi; Minson, Christopher T.; Joyner, Michael J.; Barnes, Jill N.

In: Hypertension, Vol. 66, No. 3, 14.09.2015, p. 590-597.

Research output: Contribution to journalArticle

Harvey, RE, Hart, EC, Charkoudian, N, Curry, TB, Carter, JR, Fu, Q, Minson, CT, Joyner, MJ & Barnes, JN 2015, 'Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women', Hypertension, vol. 66, no. 3, pp. 590-597. https://doi.org/10.1161/HYPERTENSIONAHA.115.05179
Harvey, Ronee E. ; Hart, Emma C. ; Charkoudian, Nisha ; Curry, Timothy B. ; Carter, Jason R. ; Fu, Qi ; Minson, Christopher T. ; Joyner, Michael J. ; Barnes, Jill N. / Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women. In: Hypertension. 2015 ; Vol. 66, No. 3. pp. 590-597.
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