Oral immunization with Acanthamoeba castellanii mannose-binding protein ameliorates amoebic keratitis

M. Garate, H. Alizadeh, S. Neelam, J. Y. Niederkorn, N. Panjwani

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In the present study, we demonstrate that oral immunization with recombinant MBP ameliorates AK in a hamster animal model and that this protection is associated with the presence of elevated levels of anti-MBP immunoglobulin A in the tear fluid of the immunized animals.

Original languageEnglish (US)
Pages (from-to)7032-7034
Number of pages3
JournalInfection and immunity
Volume74
Issue number12
DOIs
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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