Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Yukari Date, Yoichi Ueta, Hiroshi Yamashita, Hideki Yamaguchi, Shigeru Matsukura, Kenji Kangawa, Takeshi Sakurai, Masashi Yanagisawa, Masamitsu Nakazato

Research output: Contribution to journalArticle

861 Citations (Scopus)

Abstract

We determined the immunohistochemical distributions of orexin-A and orexin-B, hypothalamic peptides that function in the regulation of feeding behavior and energy homeostasis. Orexin-A and -B neurons were restricted to the lateral and posterior hypothalamus, whereas both orexin-A and -B nerve fibers projected widely into the olfactory bulb, cerebral cortex, thalamus, hypothalamus, and brainstem. Dense populations of orexin-containing fibers were present in the paraventricular thalamic nucleus, central gray, raphe nuclei, and locus coeruleus. Moderate numbers of these fibers were found in the olfactory bulb, insular, infralimbic and prelimbic cortex, amygdala, ventral, and dorsolateral parts of the suprachiasmatic nucleus, paraventricular nucleus except the lateral magnocellular division, arcuate nucleus, supramammillary nucleus, nucleus of the solitary tract, and dorsal motor nucleus of the vagus. Small numbers of orexin fibers were present in the perirhinal, motor and sensory cortex, hippocampus, and supraoptic nucleus, and a very small number in the lateral magnocellular division of the paraventricular nucleus. Intracerebroventricular injections of orexins induced c-fos expression in the paraventricular thalamic nucleus, locus coeruleus, arcuate nucleus, central gray, raphe nuclei, nucleus of the solitary tract, dorsal motor nucleus of the vagus, suprachiasmatic nucleus, supraoptic nucleus, and paraventricular nucleus except the lateral magnocellular division. The unique neuronal distribution of orexins and their functional activation of neural circuits suggest specific complex roles of the peptides in autonomic and neuroendocrine control.

Original languageEnglish (US)
Pages (from-to)748-753
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number2
DOIs
StatePublished - Jan 19 1999

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Neurosecretory Systems
Peptides
Paraventricular Hypothalamic Nucleus
Midline Thalamic Nuclei
Posterior Hypothalamus
Supraoptic Nucleus
Arcuate Nucleus of Hypothalamus
Suprachiasmatic Nucleus
Solitary Nucleus
Raphe Nuclei
Locus Coeruleus
Olfactory Bulb
Lateral Hypothalamic Area
Orexins
Feeding Behavior
Amygdala
Thalamus
Nerve Fibers
Cerebral Cortex
Hypothalamus

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. / Date, Yukari; Ueta, Yoichi; Yamashita, Hiroshi; Yamaguchi, Hideki; Matsukura, Shigeru; Kangawa, Kenji; Sakurai, Takeshi; Yanagisawa, Masashi; Nakazato, Masamitsu.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 2, 19.01.1999, p. 748-753.

Research output: Contribution to journalArticle

Date, Yukari ; Ueta, Yoichi ; Yamashita, Hiroshi ; Yamaguchi, Hideki ; Matsukura, Shigeru ; Kangawa, Kenji ; Sakurai, Takeshi ; Yanagisawa, Masashi ; Nakazato, Masamitsu. / Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 2. pp. 748-753.
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AU - Matsukura, Shigeru

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