Organ damage in high-risk patients with systemic and incomplete lupus syndromes

Nancy J. Olsen, Maha Yousif, Azza Mutwally, Melinda Cory, Nada Elmagboul, David R. Karp

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The objective of this study was to characterize organ damage in lupus patients enrolled in Dallas Regional Autoimmune Disease Registry (DRADR). Retrospective chart review was carried out on 99 patients with four or more diagnostic criteria for systemic lupus erythematosus (SLE) and 15 with less than four of these criteria, who were designated as having incomplete lupus erythematosus (ILE). The majority of patients (84 %) were African American or Hispanic/Latino; mean disease duration was 9.5 years. The mean damage score was 1.57 (range 0-8), and a damage score greater than 0 was present in 64 % of the patients. The ILE group had lower mean damage scores (0.67) than the SLE group (1.67; P = 0.04), explained in part by the shorter disease duration in the ILE patients (4.33 vs. 10.24 years; P = 0.003). The most prevalent damage category was renal, present in 24 % of patients. Malignancies occurred in individuals who were significantly older than those who had renal or peripheral vascular damage (P = 0.0007). The findings confirm clinical impressions that DRADR includes a high-risk lupus population. The ILE patients have less damage but also shorter disease duration, suggesting that this might represent an earlier disease stage. These results are consistent with the hypothesis that ILE patients include a subset that is likely to experience progressive organ damage. Longitudinal study of these patients has significant likelihood of tracking the changes that are correlated with disease progression to SLE.

Original languageEnglish (US)
Pages (from-to)2585-2590
Number of pages6
JournalRheumatology International
Volume33
Issue number10
DOIs
StatePublished - Oct 2013

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Systemic Lupus Erythematosus
Hispanic Americans
Autoimmune Diseases
Registries
Kidney
African Americans
Blood Vessels
Longitudinal Studies
Disease Progression
Population
Neoplasms

Keywords

  • Autoantibodies
  • Damage
  • Ethnicity
  • Incomplete lupus
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Organ damage in high-risk patients with systemic and incomplete lupus syndromes. / Olsen, Nancy J.; Yousif, Maha; Mutwally, Azza; Cory, Melinda; Elmagboul, Nada; Karp, David R.

In: Rheumatology International, Vol. 33, No. 10, 10.2013, p. 2585-2590.

Research output: Contribution to journalArticle

Olsen, Nancy J. ; Yousif, Maha ; Mutwally, Azza ; Cory, Melinda ; Elmagboul, Nada ; Karp, David R. / Organ damage in high-risk patients with systemic and incomplete lupus syndromes. In: Rheumatology International. 2013 ; Vol. 33, No. 10. pp. 2585-2590.
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