Organelle biogenesis in the endoplasmic reticulum

Amit S. Joshi, Hong Zhang, William A. Prinz

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Understanding organelle biogenesis is a central focus of cell biology. Whereas some are generated from existing organelles, others can be generated de novo. Most de novo organelle biogenesis occurs in the endoplasmic reticulum (ER). Here, we review the role of the ER in the generation of peroxisomes, lipid droplets, and omegasomes, which are platforms for autophagosome production, and discuss how ER subdomains with specific protein and lipid composition form and promote organelle biogenesis.

Original languageEnglish (US)
Pages (from-to)876-882
Number of pages7
JournalNature cell biology
Issue number8
StatePublished - Aug 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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