Organelle communication: Signaling crossroads between homeostasis and disease

Roberto Bravo-Sagua, Natalia Torrealba, Felipe Paredes, Pablo E. Morales, Christian Pennanen, Camila López-Crisosto, Rodrigo Troncoso, Alfredo Criollo, Mario Chiong, Joseph A Hill, Thomas Simmen, Andrew F. Quest, Sergio Lavandero

Research output: Contribution to journalShort survey

23 Scopus citations

Abstract

Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume50
Issue number1
DOIs
StatePublished - May 2014

Keywords

  • Calcium signaling
  • Endoplasmic reticulum
  • Mitochondria
  • Organelles

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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  • Cite this

    Bravo-Sagua, R., Torrealba, N., Paredes, F., Morales, P. E., Pennanen, C., López-Crisosto, C., Troncoso, R., Criollo, A., Chiong, M., Hill, J. A., Simmen, T., Quest, A. F., & Lavandero, S. (2014). Organelle communication: Signaling crossroads between homeostasis and disease. International Journal of Biochemistry and Cell Biology, 50(1), 55-59. https://doi.org/10.1016/j.biocel.2014.01.019