Organelle remodeling at membrane contact sites

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cellular organelles must execute sophisticated biological processes to persist, and often communicate with one another to exchange metabolites and information. Recent studies suggest inter-organelle membrane contact sites (MCSs) are hubs for this cellular cross-talk. MCSs also govern membrane remodeling, thus controlling aspects of organelle shape, identity, and function. Here, we summarize three emerging phenomena that MCSs appear to govern: 1) organelle identity via the non-vesicular exchange of lipids, 2) mitochondrial shape and division, and 3) endosomal migration in response to sterol trafficking. We also discuss the role for ER-endolysosomal contact sites in cholesterol metabolism, and the potential biomedical importance this holds. Indeed, the emerging field inter-organellar cross-talk promises substantial advances in the fields of lipid metabolism and cell signaling.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalJournal of Structural Biology
Volume196
Issue number1
DOIs
StatePublished - Oct 1 2016

Keywords

  • Endoplasmic Reticulum (ER)
  • Endosome
  • Membrane contact site (MCS)
  • Mitochondria
  • Phospholipid
  • Plasma membrane (PM)

ASJC Scopus subject areas

  • Structural Biology

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