TY - JOUR
T1 - Organelle remodeling at membrane contact sites
AU - Henne, W. Mike
N1 - Funding Information:
The authors would like to thank members of the Henne Lab for helpful discussions and support. This work was supported by a Welch Foundation Grant I-1873 , and the American Federation for Aging Research (AFAR) Grant A15198 . WMH is a W.W. Caruth, Jr. Endowed Scholar at UT Southwestern.
Publisher Copyright:
© 2016
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Cellular organelles must execute sophisticated biological processes to persist, and often communicate with one another to exchange metabolites and information. Recent studies suggest inter-organelle membrane contact sites (MCSs) are hubs for this cellular cross-talk. MCSs also govern membrane remodeling, thus controlling aspects of organelle shape, identity, and function. Here, we summarize three emerging phenomena that MCSs appear to govern: 1) organelle identity via the non-vesicular exchange of lipids, 2) mitochondrial shape and division, and 3) endosomal migration in response to sterol trafficking. We also discuss the role for ER-endolysosomal contact sites in cholesterol metabolism, and the potential biomedical importance this holds. Indeed, the emerging field inter-organellar cross-talk promises substantial advances in the fields of lipid metabolism and cell signaling.
AB - Cellular organelles must execute sophisticated biological processes to persist, and often communicate with one another to exchange metabolites and information. Recent studies suggest inter-organelle membrane contact sites (MCSs) are hubs for this cellular cross-talk. MCSs also govern membrane remodeling, thus controlling aspects of organelle shape, identity, and function. Here, we summarize three emerging phenomena that MCSs appear to govern: 1) organelle identity via the non-vesicular exchange of lipids, 2) mitochondrial shape and division, and 3) endosomal migration in response to sterol trafficking. We also discuss the role for ER-endolysosomal contact sites in cholesterol metabolism, and the potential biomedical importance this holds. Indeed, the emerging field inter-organellar cross-talk promises substantial advances in the fields of lipid metabolism and cell signaling.
KW - Endoplasmic Reticulum (ER)
KW - Endosome
KW - Membrane contact site (MCS)
KW - Mitochondria
KW - Phospholipid
KW - Plasma membrane (PM)
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U2 - 10.1016/j.jsb.2016.05.003
DO - 10.1016/j.jsb.2016.05.003
M3 - Article
C2 - 27181417
AN - SCOPUS:84975497221
SN - 1047-8477
VL - 196
SP - 15
EP - 19
JO - Journal of Structural Biology
JF - Journal of Structural Biology
IS - 1
ER -