Organelle-specific regulation of ferroptosis

Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is involved in the development of multiple pathological conditions, including ischemic tissue damage, infection, neurodegeneration, and cancer. The cellular machinery responsible for the execution of ferroptosis integrates multiple pro-survival or pro-death signals from subcellular organelles and then ‘decides’ whether to engage the lethal process or not. Here, we outline the evidence implicating different organelles (including mitochondria, lysosomes, endoplasmic reticulum, lipid droplets, peroxisomes, Golgi apparatus, and nucleus) in the ignition or avoidance of ferroptosis, while emphasizing their potential relevance for human disease and their targetability for pharmacological interventions.

Original languageEnglish (US)
Pages (from-to)2843-2856
Number of pages14
JournalCell Death and Differentiation
Volume28
Issue number10
DOIs
StatePublished - Oct 2021

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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