Organization and evolution of D region class I genes in the mouse major histocompatibility complex

D. Stephan, H. Sun, K. F. Lindahl, E. Meyer, G. Hämmerling, L. Hood, M. Steinmetz

Research output: Contribution to journalArticle

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Abstract

Chromosome walking has been used to study the organization of the class I genes in the D and Qa regions of the MHC of the BALB/c mouse and in the D region of the AKR mouse. Five and eight class I genes are found in the D and Qa regions of the BALB/c mouse, respectively, while the AKR mouse contains only a single class I D region gene that has been identified by transfection as the D(k) gene. Restriction map homologies and crosshybridization experiments suggest that the multiple class I genes in the D region of the BALB/c mouse have been generated by unequal crossing-over involving class I genes from the Qa region. The expanded D region of BALB/c and other H-2(d) haplotype mouse strains appears to be metastable, since evidence for gene contraction in the D(d) region has been found in two mutant strains. Thus the D region and also the Qa region class I genes are in a dynamic state, evolving by gene expansion and contraction.

Original languageEnglish (US)
Pages (from-to)1227-1244
Number of pages18
JournalJournal of Experimental Medicine
Volume163
Issue number5
DOIs
StatePublished - 1986

Fingerprint

MHC Class I Genes
Major Histocompatibility Complex
Inbred AKR Mouse
Genes
Chromosome Walking
Haplotypes
Transfection

ASJC Scopus subject areas

  • Immunology

Cite this

Stephan, D., Sun, H., Lindahl, K. F., Meyer, E., Hämmerling, G., Hood, L., & Steinmetz, M. (1986). Organization and evolution of D region class I genes in the mouse major histocompatibility complex. Journal of Experimental Medicine, 163(5), 1227-1244. https://doi.org/10.1084/jem.163.5.1227

Organization and evolution of D region class I genes in the mouse major histocompatibility complex. / Stephan, D.; Sun, H.; Lindahl, K. F.; Meyer, E.; Hämmerling, G.; Hood, L.; Steinmetz, M.

In: Journal of Experimental Medicine, Vol. 163, No. 5, 1986, p. 1227-1244.

Research output: Contribution to journalArticle

Stephan, D, Sun, H, Lindahl, KF, Meyer, E, Hämmerling, G, Hood, L & Steinmetz, M 1986, 'Organization and evolution of D region class I genes in the mouse major histocompatibility complex', Journal of Experimental Medicine, vol. 163, no. 5, pp. 1227-1244. https://doi.org/10.1084/jem.163.5.1227
Stephan, D. ; Sun, H. ; Lindahl, K. F. ; Meyer, E. ; Hämmerling, G. ; Hood, L. ; Steinmetz, M. / Organization and evolution of D region class I genes in the mouse major histocompatibility complex. In: Journal of Experimental Medicine. 1986 ; Vol. 163, No. 5. pp. 1227-1244.
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