Organization of the immune response genes

Jonathan W. Uhr, J. Donald Capra, Ellen S. Vitetta, Richard G. Cook

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The / region of the major histocompatibility complex contains immune response genes that display considerable polymorphism; that is, there are many alleles at each locus. These genes regulate the immune response to antigen by mediating intercellular communication among lymphoreticular cells. An analysis of the primary structure of the products of two subregions of / (I-A, I-E/C) was undertaken in order to understand the genetic organization of the region, the evolution of the genes and, eventually, their function.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalScience
Volume206
Issue number4416
StatePublished - 1979

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Genes
Histocompatibility Antigens Class II
Major Histocompatibility Complex
Alleles

ASJC Scopus subject areas

  • General

Cite this

Uhr, J. W., Donald Capra, J., Vitetta, E. S., & Cook, R. G. (1979). Organization of the immune response genes. Science, 206(4416), 292-297.

Organization of the immune response genes. / Uhr, Jonathan W.; Donald Capra, J.; Vitetta, Ellen S.; Cook, Richard G.

In: Science, Vol. 206, No. 4416, 1979, p. 292-297.

Research output: Contribution to journalArticle

Uhr, JW, Donald Capra, J, Vitetta, ES & Cook, RG 1979, 'Organization of the immune response genes', Science, vol. 206, no. 4416, pp. 292-297.
Uhr JW, Donald Capra J, Vitetta ES, Cook RG. Organization of the immune response genes. Science. 1979;206(4416):292-297.
Uhr, Jonathan W. ; Donald Capra, J. ; Vitetta, Ellen S. ; Cook, Richard G. / Organization of the immune response genes. In: Science. 1979 ; Vol. 206, No. 4416. pp. 292-297.
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