Organization of the immune response genes

Jonathan W. Uhr, J. Donald Capra, Ellen S. Vitetta, Richard G. Cook

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

The / region of the major histocompatibility complex contains immune response genes that display considerable polymorphism; that is, there are many alleles at each locus. These genes regulate the immune response to antigen by mediating intercellular communication among lymphoreticular cells. An analysis of the primary structure of the products of two subregions of / (I-A, I-E/C) was undertaken in order to understand the genetic organization of the region, the evolution of the genes and, eventually, their function.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalScience
Volume206
Issue number4416
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • General

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    Uhr, J. W., Donald Capra, J., Vitetta, E. S., & Cook, R. G. (1979). Organization of the immune response genes. Science, 206(4416), 292-297. https://doi.org/10.1126/science.113876