Organocatalytic enantioselective formal C(sp2)-H alkylation

Madhu Sudan Manna, Santanu Mukherjee

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

An organocatalytic enantioselective formal C(sp2)-H alkylation is reported. This alkylative desymmetrization of prochiral 2,2-disubstituted cyclopentene-1,3-dione is catalyzed by a bifunctional tertiary aminourea derivative, utilizes air-stable and inexpensive nitroalkanes as the alkylating agents, and delivers synthetically versatile five-membered carbocycles containing an all-carbon quaternary stereogenic center remote from the reaction site in excellent enantioselectivity.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number1
DOIs
StatePublished - Jan 14 2015
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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