Organocopper-mediated two-component S N2'-substitution cascade towards N-fused heterocycles

D. Chernyak, V. Gevorgyan

Research output: Contribution to journalArticle

Abstract

Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an S N2'-substitution followed by a consequent cycloisomerization step.

Original languageEnglish (US)
Pages (from-to)1816-1827
Number of pages12
JournalKhimiya Geterotsiklicheskikh Soedinenii
Issue number12
StatePublished - Dec 1 2011
Externally publishedYes

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Mesylates
Copper
Substitution reactions
Temperature

Keywords

  • Allenes
  • Cycloisomerization
  • Indolizines
  • Propargyl mesylates
  • Synthetic methods

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Organocopper-mediated two-component S N2'-substitution cascade towards N-fused heterocycles. / Chernyak, D.; Gevorgyan, V.

In: Khimiya Geterotsiklicheskikh Soedinenii, No. 12, 01.12.2011, p. 1816-1827.

Research output: Contribution to journalArticle

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