Organocopper-mediated two-component SN2’-substitution cascade towards N-fused heterocycles

D. Chernyak, V. Gevorgyan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a “double duty” in this cascade transformation, which proceeds through an SN2’-substitution followed by a consequent cycloisomerization step.

Original languageEnglish (US)
Pages (from-to)1516-1526
Number of pages11
JournalChemistry of Heterocyclic Compounds
Volume47
Issue number12
StatePublished - Mar 1 2012
Externally publishedYes

Keywords

  • Allenes
  • Cycloisomerization
  • Indolizines
  • Propargyl mesylates
  • Synthetic methods

ASJC Scopus subject areas

  • Organic Chemistry

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