Origin of estrogen in normal men and in women with testicular feminization

P. C. MacDonald, J. D. Madden, P. F. Brenner, J. D. Wilson, P. K. Siiteri

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

The purpose of this study was to quantify the various sources of estrone (E 1) and 17β-estradiol (E 2) production in normal men and in women with testicular feminization. The mean production rate of E 1 in four young adult men was 58 μg/24 h, while that of E 2 was 44 μg/24 h. In these men, E 1 production could be accounted for totally by extraglandular formation through 1) aromatization of plasma androstenedione, 2) conversion of E 2 which was formed from the aromatization of plasma testosterone, and 3) conversion of secreted E 2. In these men, only 12 μg or less of E 2 production could not be accounted for by extraglandular formation from plasma C 19 precursors, and is presumed to have arisen by testicular secretion. In six women with testicular feminization, the mean production rate of E 1 was 99 μg/24h, while that of E 2 was 77 μg/24 h. The amount of E 2 production that arose by glandular secretion could be computed in four of these women and was considerably greater than that found in the young adult men. In these women with testicular feminization, an average of 44 μg/24 h E 2 could not be accounted for by extraglandular formation and is presumed to have arisen by testicular secretion. The mean plasma production rate of testosterone in the normal men was 5.7 mg/24 h, while that in the women with testicular feminization was 8.3 mg/24 h. However, the range of plasma production rates of testosterone in the women with testicular feminization was large.

Original languageEnglish (US)
Pages (from-to)905-916
Number of pages12
JournalJournal of Clinical Endocrinology and Metabolism
Volume49
Issue number6
StatePublished - 1979

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Androgen-Insensitivity Syndrome
Estrogens
Testosterone
Aromatization
Plasma sources
Plasmas
Young Adult
Androstenedione
Estrone
Estradiol

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

MacDonald, P. C., Madden, J. D., Brenner, P. F., Wilson, J. D., & Siiteri, P. K. (1979). Origin of estrogen in normal men and in women with testicular feminization. Journal of Clinical Endocrinology and Metabolism, 49(6), 905-916.

Origin of estrogen in normal men and in women with testicular feminization. / MacDonald, P. C.; Madden, J. D.; Brenner, P. F.; Wilson, J. D.; Siiteri, P. K.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 49, No. 6, 1979, p. 905-916.

Research output: Contribution to journalArticle

MacDonald, PC, Madden, JD, Brenner, PF, Wilson, JD & Siiteri, PK 1979, 'Origin of estrogen in normal men and in women with testicular feminization', Journal of Clinical Endocrinology and Metabolism, vol. 49, no. 6, pp. 905-916.
MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK. Origin of estrogen in normal men and in women with testicular feminization. Journal of Clinical Endocrinology and Metabolism. 1979;49(6):905-916.
MacDonald, P. C. ; Madden, J. D. ; Brenner, P. F. ; Wilson, J. D. ; Siiteri, P. K. / Origin of estrogen in normal men and in women with testicular feminization. In: Journal of Clinical Endocrinology and Metabolism. 1979 ; Vol. 49, No. 6. pp. 905-916.
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