Origin of peripheral venous hypersomatostatinemia in alloxan-diabetic dogs

V. Schusdziarra, D. Rouiller, V. Harris, Roger H Unger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Basal and postprandial somatostatin-like immunoreactivity (SLI) is elevated in the peripheral venous plasma of chronic alloxan-diabetic dogs. To determine if this hypersomatostatinemia was the consequence of increased somatostatin release from the pancreas, stomach, or both, plasma SLI was measured in the pancreaticoduodenal, antral, and fundic veins and in the inferior vena cava in response to stimulation by a gastric liver test meal, followed by an intragastric HCl load. Basal and postprandial inferior vena caval plasma SLI levels were significantly higher than the control level (P<0.05-0.001), confirming earlier findings. Basal pancreatic venous SLI was 780 ± 45 pg/ml in the diabetic dogs and 493 ± 65 pg/ml in the controls (P<0.02). In response to the liver meal at pH 7, the incremental pancreatic venous SLI level in the diabetic dogs was 1630 ± 95 pg/ml, and after HCl it rose to 9479 ± 384 pg/ml compared to 938 ± 80 and 4677 ± 192 pg/ml, respectively, in the controls (P<0.02 and P<0.005). However, antral and fundic venous SLI levels in the diabetic dogs did not differ from the controls in either basal or stimulated states. The present data demonstrate that the pancreas and not the stomach is the probable source of the peripheral hypersomatostatinemia of alloxan-diabetic dogs.

Original languageEnglish (US)
Pages (from-to)1107-1110
Number of pages4
JournalEndocrinology
Volume109
Issue number4
StatePublished - 1981

Fingerprint

Alloxan
Dogs
Stomach
Meals
Pancreas
Venae Cavae
Liver
Inferior Vena Cava
Somatostatin
somatostatin-like peptides
Veins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Schusdziarra, V., Rouiller, D., Harris, V., & Unger, R. H. (1981). Origin of peripheral venous hypersomatostatinemia in alloxan-diabetic dogs. Endocrinology, 109(4), 1107-1110.

Origin of peripheral venous hypersomatostatinemia in alloxan-diabetic dogs. / Schusdziarra, V.; Rouiller, D.; Harris, V.; Unger, Roger H.

In: Endocrinology, Vol. 109, No. 4, 1981, p. 1107-1110.

Research output: Contribution to journalArticle

Schusdziarra, V, Rouiller, D, Harris, V & Unger, RH 1981, 'Origin of peripheral venous hypersomatostatinemia in alloxan-diabetic dogs', Endocrinology, vol. 109, no. 4, pp. 1107-1110.
Schusdziarra, V. ; Rouiller, D. ; Harris, V. ; Unger, Roger H. / Origin of peripheral venous hypersomatostatinemia in alloxan-diabetic dogs. In: Endocrinology. 1981 ; Vol. 109, No. 4. pp. 1107-1110.
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