Origins and activity of the Mediator complex

Ronald C. Conaway, Joan Weliky Conaway

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in. Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number7
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Mediator
  • RNA polymerase II
  • Transcription

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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