Orphan nuclear receptors

Shifting endocrinology into reverse

Steven A. Kliewer, Jürgen M. Lehmann, Timothy M. Willson

Research output: Contribution to journalArticle

405 Citations (Scopus)

Abstract

Steroid and thyroid hormones and vitamin A metabolites (retinoids) regulate the expression of complex gene programs by binding to members of the nuclear receptor family of ligand-activated transcription factors. The nuclear receptor family also includes many 'orphan' members that currently lack known ligands but that represent candidate receptors for new hormones. Recently, natural and synthetic ligands have been identified for several orphan receptors and used to dissect their biological roles. This 'reverse endocrinology' strategy has resulted in the discovery of unanticipated nuclear signaling pathways for retinoids, fatty acids, eicosanoids, and steroids with important physiological and pharmacological ramifications.

Original languageEnglish (US)
Pages (from-to)757-760
Number of pages4
JournalScience
Volume284
Issue number5415
DOIs
StatePublished - Apr 30 1999

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Orphan Nuclear Receptors
Endocrinology
Retinoids
Cytoplasmic and Nuclear Receptors
Ligands
Nuclear Family
Steroids
Eicosanoids
Vitamin A
Thyroid Hormones
Transcription Factors
Fatty Acids
Hormones
Pharmacology
Gene Expression

ASJC Scopus subject areas

  • General

Cite this

Orphan nuclear receptors : Shifting endocrinology into reverse. / Kliewer, Steven A.; Lehmann, Jürgen M.; Willson, Timothy M.

In: Science, Vol. 284, No. 5415, 30.04.1999, p. 757-760.

Research output: Contribution to journalArticle

Kliewer, Steven A. ; Lehmann, Jürgen M. ; Willson, Timothy M. / Orphan nuclear receptors : Shifting endocrinology into reverse. In: Science. 1999 ; Vol. 284, No. 5415. pp. 757-760.
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