Orthotopic Heart Transplantation in a Child With Hereditary Spherocytosis

Charles E. Johnson, Michael L. Schmitz, Wesley A. McKamie, R. Erik Edens, Michiaki Imamura, Robert D B Jaquiss

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Hereditary spherocytosis (HS) is a genetic, frequently familial hemolytic blood disease that presents with varying degrees of hemolytic anemia, splenomegaly, and jaundice. The disease arises as a result of defects in any of a number of proteins responsible for maintaining the shape and flexibility of the red blood cell, resulting in an osmotically fragile and characteristically spherical red blood cell. Theoretically, cardiopulmonary bypass can exacerbate hemolysis and subsequent renal dysfunction. There are few reports of open heart surgery for patients with HS and none for orthotopic heart transplantation. We report a 6-year-old boy with HS who underwent orthotopic heart transplantation.

Original languageEnglish (US)
Pages (from-to)1154-1156
Number of pages3
JournalArtificial Organs
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • Cardiopulmonary bypass
  • Heart transplantation
  • Hereditary spherocytosis
  • Pediatric

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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