Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease

Arenda H E A van Beek, Joep Lagro, Marcel G M Olde-Rikkert, Rong Zhang, Jurgen A H R Claassen

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In Alzheimer's disease (AD) cerebrovascular function is at risk. Transcranial Doppler, near-infrared spectroscopy, and photoplethysmography are noninvasive methods to continuously measure changes in cerebral blood flow velocity (CBFV), cerebral cortical oxygenated hemoglobin (O 2Hb), and blood pressure (BP). In 21 patients with mild to moderate AD and 20 age-matched controls, we investigated how oscillations in cerebral blood flow velocity (CBFV) and O 2Hb are associated with spontaneous and induced oscillations in blood pressure (BP) at the very low (VLF = 0.05 Hz) and low frequencies (LF = 0.1 Hz). We applied spectral and transfer function analysis to quantify dynamic cerebral autoregulation and brain tissue oxygenation. In AD, cerebrovascular resistance was substantially higher (34%, AD vs. control: δ = 0.69 (0.25) mm Hg/cm/second, p = 0.012) and the transmission of very low frequency (VLF) cerebral blood flow (CBF) oscillations into O 2Hb differed, with increased phase lag and gain (δ phase 0.32 [0.15] rad; δ gain 0.049 [0.014] μmol/cm/second, p both < 0.05). The altered transfer of CBF to cortical oxygenation in AD indicates that properties of the cerebral microvasculature are changed in this disease.

Original languageEnglish (US)
JournalNeurobiology of Aging
Volume33
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Cerebrovascular Circulation
Alzheimer Disease
Blood Flow Velocity
Photoplethysmography
Blood Pressure
Near-Infrared Spectroscopy
Microvessels
Hemoglobins
Homeostasis
Brain

Keywords

  • Alzheimer's disease
  • Brain tissue oxygenation
  • Cerebral autoregulation
  • Cerebrovascular disease
  • Near infrared spectroscopy
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease. / van Beek, Arenda H E A; Lagro, Joep; Olde-Rikkert, Marcel G M; Zhang, Rong; Claassen, Jurgen A H R.

In: Neurobiology of Aging, Vol. 33, No. 2, 02.2012.

Research output: Contribution to journalArticle

van Beek, Arenda H E A ; Lagro, Joep ; Olde-Rikkert, Marcel G M ; Zhang, Rong ; Claassen, Jurgen A H R. / Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 2.
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