Oseltamivir use among children and adults hospitalized with community-acquired pneumonia

Ikwo K. Oboho, Anna Bramley, Lyn Finelli, Alicia Fry, Krow Ampofo, Sandra R. Arnold, Wesley H. Self, Derek J. Williams, D. Mark Courtney, Yuwei Zhu, Evan J. Anderson, Carlos G. Grijalva, Jonathan A. McCullers, Richard G. Wunderink, Andrew T. Pavia, Kathryn M. Edwards, Seema Jain

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. Methods. Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. Results. Oseltamivir treatment was provided to 89 of 1627 (5%) children (< 18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir. Among children, oseltamivir treatment was associated with hospital A (adjusted odds ratio [aOR], 2.76; 95% confidence interval [CI], 1.36-4.88), clinician-ordered testing performed (aOR, 2.44; 95% CI, 1.47-5.19), intensive care unit (ICU) admission (aOR, 2.09; 95% CI, 1.27-3.45), and age ≥2 years (aOR, 1.43; 95% CI, 1.16-1.76). Among adults, oseltamivir treatment was associated with clinician- ordered testing performed (aOR, 8.38; 95% CI, 4.64-15.12), hospitals D and E (aOR, 3.46-5.11; 95% CI, 1.75-11.01), Hispanic ethnicity (aOR, 2.06; 95% CI, 1.18-3.59), and ICU admission (aOR, 2.05; 95% CI, 1.34-3.13). Conclusions. Among patients hospitalized with CAP during influenza season, oseltamivir treatment was moderate overall and associated with clinician-ordered testing, severe illness, and specific hospitals. Increased clinician education is needed to include influenza in the differential diagnosis for hospitalized CAP patients and to test and treat patients empirically if influenza is suspected.

Original languageEnglish (US)
Article numberofw254
JournalOpen Forum Infectious Diseases
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Oseltamivir
Hospitalized Child
Pneumonia
Odds Ratio
Confidence Intervals
Human Influenza
Intensive Care Units
Therapeutics
Hispanic Americans
Differential Diagnosis
Logistic Models
Education

Keywords

  • Community-acquired pneumonia
  • Influenza
  • Oseltamivir

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

Cite this

Oboho, I. K., Bramley, A., Finelli, L., Fry, A., Ampofo, K., Arnold, S. R., ... Jain, S. (2017). Oseltamivir use among children and adults hospitalized with community-acquired pneumonia. Open Forum Infectious Diseases, 4(1), [ofw254]. https://doi.org/10.1093/oid/ofw254

Oseltamivir use among children and adults hospitalized with community-acquired pneumonia. / Oboho, Ikwo K.; Bramley, Anna; Finelli, Lyn; Fry, Alicia; Ampofo, Krow; Arnold, Sandra R.; Self, Wesley H.; Williams, Derek J.; Mark Courtney, D.; Zhu, Yuwei; Anderson, Evan J.; Grijalva, Carlos G.; McCullers, Jonathan A.; Wunderink, Richard G.; Pavia, Andrew T.; Edwards, Kathryn M.; Jain, Seema.

In: Open Forum Infectious Diseases, Vol. 4, No. 1, ofw254, 01.01.2017.

Research output: Contribution to journalArticle

Oboho, IK, Bramley, A, Finelli, L, Fry, A, Ampofo, K, Arnold, SR, Self, WH, Williams, DJ, Mark Courtney, D, Zhu, Y, Anderson, EJ, Grijalva, CG, McCullers, JA, Wunderink, RG, Pavia, AT, Edwards, KM & Jain, S 2017, 'Oseltamivir use among children and adults hospitalized with community-acquired pneumonia', Open Forum Infectious Diseases, vol. 4, no. 1, ofw254. https://doi.org/10.1093/oid/ofw254
Oboho, Ikwo K. ; Bramley, Anna ; Finelli, Lyn ; Fry, Alicia ; Ampofo, Krow ; Arnold, Sandra R. ; Self, Wesley H. ; Williams, Derek J. ; Mark Courtney, D. ; Zhu, Yuwei ; Anderson, Evan J. ; Grijalva, Carlos G. ; McCullers, Jonathan A. ; Wunderink, Richard G. ; Pavia, Andrew T. ; Edwards, Kathryn M. ; Jain, Seema. / Oseltamivir use among children and adults hospitalized with community-acquired pneumonia. In: Open Forum Infectious Diseases. 2017 ; Vol. 4, No. 1.
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AU - Oboho, Ikwo K.

AU - Bramley, Anna

AU - Finelli, Lyn

AU - Fry, Alicia

AU - Ampofo, Krow

AU - Arnold, Sandra R.

AU - Self, Wesley H.

AU - Williams, Derek J.

AU - Mark Courtney, D.

AU - Zhu, Yuwei

AU - Anderson, Evan J.

AU - Grijalva, Carlos G.

AU - McCullers, Jonathan A.

AU - Wunderink, Richard G.

AU - Pavia, Andrew T.

AU - Edwards, Kathryn M.

AU - Jain, Seema

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N2 - Background. Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. Methods. Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. Results. Oseltamivir treatment was provided to 89 of 1627 (5%) children (< 18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir. Among children, oseltamivir treatment was associated with hospital A (adjusted odds ratio [aOR], 2.76; 95% confidence interval [CI], 1.36-4.88), clinician-ordered testing performed (aOR, 2.44; 95% CI, 1.47-5.19), intensive care unit (ICU) admission (aOR, 2.09; 95% CI, 1.27-3.45), and age ≥2 years (aOR, 1.43; 95% CI, 1.16-1.76). Among adults, oseltamivir treatment was associated with clinician- ordered testing performed (aOR, 8.38; 95% CI, 4.64-15.12), hospitals D and E (aOR, 3.46-5.11; 95% CI, 1.75-11.01), Hispanic ethnicity (aOR, 2.06; 95% CI, 1.18-3.59), and ICU admission (aOR, 2.05; 95% CI, 1.34-3.13). Conclusions. Among patients hospitalized with CAP during influenza season, oseltamivir treatment was moderate overall and associated with clinician-ordered testing, severe illness, and specific hospitals. Increased clinician education is needed to include influenza in the differential diagnosis for hospitalized CAP patients and to test and treat patients empirically if influenza is suspected.

AB - Background. Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. Methods. Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. Results. Oseltamivir treatment was provided to 89 of 1627 (5%) children (< 18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir. Among children, oseltamivir treatment was associated with hospital A (adjusted odds ratio [aOR], 2.76; 95% confidence interval [CI], 1.36-4.88), clinician-ordered testing performed (aOR, 2.44; 95% CI, 1.47-5.19), intensive care unit (ICU) admission (aOR, 2.09; 95% CI, 1.27-3.45), and age ≥2 years (aOR, 1.43; 95% CI, 1.16-1.76). Among adults, oseltamivir treatment was associated with clinician- ordered testing performed (aOR, 8.38; 95% CI, 4.64-15.12), hospitals D and E (aOR, 3.46-5.11; 95% CI, 1.75-11.01), Hispanic ethnicity (aOR, 2.06; 95% CI, 1.18-3.59), and ICU admission (aOR, 2.05; 95% CI, 1.34-3.13). Conclusions. Among patients hospitalized with CAP during influenza season, oseltamivir treatment was moderate overall and associated with clinician-ordered testing, severe illness, and specific hospitals. Increased clinician education is needed to include influenza in the differential diagnosis for hospitalized CAP patients and to test and treat patients empirically if influenza is suspected.

KW - Community-acquired pneumonia

KW - Influenza

KW - Oseltamivir

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