Abstract
Background. Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. Methods. Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. Results. Oseltamivir treatment was provided to 89 of 1627 (5%) children (< 18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir. Among children, oseltamivir treatment was associated with hospital A (adjusted odds ratio [aOR], 2.76; 95% confidence interval [CI], 1.36-4.88), clinician-ordered testing performed (aOR, 2.44; 95% CI, 1.47-5.19), intensive care unit (ICU) admission (aOR, 2.09; 95% CI, 1.27-3.45), and age ≥2 years (aOR, 1.43; 95% CI, 1.16-1.76). Among adults, oseltamivir treatment was associated with clinician- ordered testing performed (aOR, 8.38; 95% CI, 4.64-15.12), hospitals D and E (aOR, 3.46-5.11; 95% CI, 1.75-11.01), Hispanic ethnicity (aOR, 2.06; 95% CI, 1.18-3.59), and ICU admission (aOR, 2.05; 95% CI, 1.34-3.13). Conclusions. Among patients hospitalized with CAP during influenza season, oseltamivir treatment was moderate overall and associated with clinician-ordered testing, severe illness, and specific hospitals. Increased clinician education is needed to include influenza in the differential diagnosis for hospitalized CAP patients and to test and treat patients empirically if influenza is suspected.
| Original language | English (US) |
|---|---|
| Article number | ofw254 |
| Journal | Open Forum Infectious Diseases |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
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Keywords
- Community-acquired pneumonia
- Influenza
- Oseltamivir
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
Cite this
Oseltamivir use among children and adults hospitalized with community-acquired pneumonia. / Oboho, Ikwo K.; Bramley, Anna; Finelli, Lyn; Fry, Alicia; Ampofo, Krow; Arnold, Sandra R.; Self, Wesley H.; Williams, Derek J.; Mark Courtney, D.; Zhu, Yuwei; Anderson, Evan J.; Grijalva, Carlos G.; McCullers, Jonathan A.; Wunderink, Richard G.; Pavia, Andrew T.; Edwards, Kathryn M.; Jain, Seema.
In: Open Forum Infectious Diseases, Vol. 4, No. 1, ofw254, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oseltamivir use among children and adults hospitalized with community-acquired pneumonia
AU - Oboho, Ikwo K.
AU - Bramley, Anna
AU - Finelli, Lyn
AU - Fry, Alicia
AU - Ampofo, Krow
AU - Arnold, Sandra R.
AU - Self, Wesley H.
AU - Williams, Derek J.
AU - Mark Courtney, D.
AU - Zhu, Yuwei
AU - Anderson, Evan J.
AU - Grijalva, Carlos G.
AU - McCullers, Jonathan A.
AU - Wunderink, Richard G.
AU - Pavia, Andrew T.
AU - Edwards, Kathryn M.
AU - Jain, Seema
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background. Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. Methods. Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. Results. Oseltamivir treatment was provided to 89 of 1627 (5%) children (< 18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir. Among children, oseltamivir treatment was associated with hospital A (adjusted odds ratio [aOR], 2.76; 95% confidence interval [CI], 1.36-4.88), clinician-ordered testing performed (aOR, 2.44; 95% CI, 1.47-5.19), intensive care unit (ICU) admission (aOR, 2.09; 95% CI, 1.27-3.45), and age ≥2 years (aOR, 1.43; 95% CI, 1.16-1.76). Among adults, oseltamivir treatment was associated with clinician- ordered testing performed (aOR, 8.38; 95% CI, 4.64-15.12), hospitals D and E (aOR, 3.46-5.11; 95% CI, 1.75-11.01), Hispanic ethnicity (aOR, 2.06; 95% CI, 1.18-3.59), and ICU admission (aOR, 2.05; 95% CI, 1.34-3.13). Conclusions. Among patients hospitalized with CAP during influenza season, oseltamivir treatment was moderate overall and associated with clinician-ordered testing, severe illness, and specific hospitals. Increased clinician education is needed to include influenza in the differential diagnosis for hospitalized CAP patients and to test and treat patients empirically if influenza is suspected.
AB - Background. Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. Methods. Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. Results. Oseltamivir treatment was provided to 89 of 1627 (5%) children (< 18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir. Among children, oseltamivir treatment was associated with hospital A (adjusted odds ratio [aOR], 2.76; 95% confidence interval [CI], 1.36-4.88), clinician-ordered testing performed (aOR, 2.44; 95% CI, 1.47-5.19), intensive care unit (ICU) admission (aOR, 2.09; 95% CI, 1.27-3.45), and age ≥2 years (aOR, 1.43; 95% CI, 1.16-1.76). Among adults, oseltamivir treatment was associated with clinician- ordered testing performed (aOR, 8.38; 95% CI, 4.64-15.12), hospitals D and E (aOR, 3.46-5.11; 95% CI, 1.75-11.01), Hispanic ethnicity (aOR, 2.06; 95% CI, 1.18-3.59), and ICU admission (aOR, 2.05; 95% CI, 1.34-3.13). Conclusions. Among patients hospitalized with CAP during influenza season, oseltamivir treatment was moderate overall and associated with clinician-ordered testing, severe illness, and specific hospitals. Increased clinician education is needed to include influenza in the differential diagnosis for hospitalized CAP patients and to test and treat patients empirically if influenza is suspected.
KW - Community-acquired pneumonia
KW - Influenza
KW - Oseltamivir
UR - http://www.scopus.com/inward/record.url?scp=85014323309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014323309&partnerID=8YFLogxK
U2 - 10.1093/oid/ofw254
DO - 10.1093/oid/ofw254
M3 - Article
AN - SCOPUS:85014323309
VL - 4
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 1
M1 - ofw254
ER -