Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery

E. A. Neuwelt, K. R. Maravilla, E. P. Frenkel, S. I. Rapaport, S. A. Hill, P. A. Barnett

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.

Original languageEnglish (US)
Pages (from-to)684-688
Number of pages5
JournalJournal of Clinical Investigation
Volume64
Issue number2
StatePublished - 1979

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Blood-Brain Barrier
Canidae
Cerebrum
Internal Carotid Artery
Mannitol
Methotrexate
Cerebrospinal Fluid
Brain
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuwelt, E. A., Maravilla, K. R., Frenkel, E. P., Rapaport, S. I., Hill, S. A., & Barnett, P. A. (1979). Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. Journal of Clinical Investigation, 64(2), 684-688.

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. / Neuwelt, E. A.; Maravilla, K. R.; Frenkel, E. P.; Rapaport, S. I.; Hill, S. A.; Barnett, P. A.

In: Journal of Clinical Investigation, Vol. 64, No. 2, 1979, p. 684-688.

Research output: Contribution to journalArticle

Neuwelt, EA, Maravilla, KR, Frenkel, EP, Rapaport, SI, Hill, SA & Barnett, PA 1979, 'Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery', Journal of Clinical Investigation, vol. 64, no. 2, pp. 684-688.
Neuwelt, E. A. ; Maravilla, K. R. ; Frenkel, E. P. ; Rapaport, S. I. ; Hill, S. A. ; Barnett, P. A. / Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. In: Journal of Clinical Investigation. 1979 ; Vol. 64, No. 2. pp. 684-688.
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