Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors

E. A. Neuwelt, S. A. Hill, E. P. Frenkel, J. T. Diehl, K. R. Maravilla, L. H. Vu, W. K. Clark, S. I. Rapoport, P. A. Barnett, S. E. Lewis, A. L. Ehle, C. W. Beyer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Infusion of 25% mannitol in saline into the internal carotid artery of dogs disrupts the blood-brain barrier (BBB) in a controlled and reproducible manner (osmotic disruption), whereas mannitol infused through the common carotid artery produces variable disruption of the BBB. Compared to controls, infusion of methotrexate in dogs after osmotic disruption produced significantly higher drug levels in brain. We report very preliminary data on the effects of osmotic disruption with mannitol in five patients harboring malignant brain tumors.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalCancer Treatment Reports
Volume65
Issue numberSuppl. 2
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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