Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors

E. A. Neuwelt; S. A. Hill; E. P. Frenkel; J. T. Diehl; K. R. Maravilla; L. H. Vu; W. K. Clark; S. I. Rapoport; P. A. Barnett; S. E. Lewis; A. L. Ehle; C. W. Beyer

Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors

E. A. Neuwelt, S. A. Hill, E. P. Frenkel, J. T. Diehl, K. R. Maravilla, L. H. Vu, W. K. Clark, S. I. Rapoport, P. A. Barnett, S. E. Lewis, A. L. Ehle, C. W. Beyer

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31 Scopus citations

Abstract

Infusion of 25% mannitol in saline into the internal carotid artery of dogs disrupts the blood-brain barrier (BBB) in a controlled and reproducible manner (osmotic disruption), whereas mannitol infused through the common carotid artery produces variable disruption of the BBB. Compared to controls, infusion of methotrexate in dogs after osmotic disruption produced significantly higher drug levels in brain. We report very preliminary data on the effects of osmotic disruption with mannitol in five patients harboring malignant brain tumors.

Original language	English (US)
Pages (from-to)	39-43
Number of pages	5
Journal	Cancer Treatment Reports
Volume	65
Issue number	Suppl. 2
State	Published - Dec 1 1981

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

Neuwelt, E. A., Hill, S. A., Frenkel, E. P., Diehl, J. T., Maravilla, K. R., Vu, L. H., Clark, W. K., Rapoport, S. I., Barnett, P. A., Lewis, S. E., Ehle, A. L., & Beyer, C. W. (1981). Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors. Cancer Treatment Reports, 65(Suppl. 2), 39-43.

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abstract = "Infusion of 25% mannitol in saline into the internal carotid artery of dogs disrupts the blood-brain barrier (BBB) in a controlled and reproducible manner (osmotic disruption), whereas mannitol infused through the common carotid artery produces variable disruption of the BBB. Compared to controls, infusion of methotrexate in dogs after osmotic disruption produced significantly higher drug levels in brain. We report very preliminary data on the effects of osmotic disruption with mannitol in five patients harboring malignant brain tumors.",

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AU - Frenkel, E. P.

AU - Diehl, J. T.

AU - Maravilla, K. R.

AU - Vu, L. H.

AU - Clark, W. K.

AU - Rapoport, S. I.

AU - Barnett, P. A.

AU - Lewis, S. E.

AU - Ehle, A. L.

AU - Beyer, C. W.

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AB - Infusion of 25% mannitol in saline into the internal carotid artery of dogs disrupts the blood-brain barrier (BBB) in a controlled and reproducible manner (osmotic disruption), whereas mannitol infused through the common carotid artery produces variable disruption of the BBB. Compared to controls, infusion of methotrexate in dogs after osmotic disruption produced significantly higher drug levels in brain. We report very preliminary data on the effects of osmotic disruption with mannitol in five patients harboring malignant brain tumors.

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Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors

Abstract

ASJC Scopus subject areas

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