Osmotic blood-brain barrier disruption

Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors

E. A. Neuwelt, S. A. Hill, E. P. Frenkel, J. T. Diehl, K. R. Maravilla, L. H. Vu, W. K. Clark, S. I. Rapoport, P. A. Barnett, S. E. Lewis, A. L. Ehle, C. W. Beyer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Infusion of 25% mannitol in saline into the internal carotid artery of dogs disrupts the blood-brain barrier (BBB) in a controlled and reproducible manner (osmotic disruption), whereas mannitol infused through the common carotid artery produces variable disruption of the BBB. Compared to controls, infusion of methotrexate in dogs after osmotic disruption produced significantly higher drug levels in brain. We report very preliminary data on the effects of osmotic disruption with mannitol in five patients harboring malignant brain tumors.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalCancer Treatment Reports
Volume65
Issue numberSuppl. 2
StatePublished - 1981

Fingerprint

Clinical Trials, Phase I
Mannitol
Blood-Brain Barrier
Brain Neoplasms
Dogs
Common Carotid Artery
Internal Carotid Artery
Methotrexate
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Neuwelt, E. A., Hill, S. A., Frenkel, E. P., Diehl, J. T., Maravilla, K. R., Vu, L. H., ... Beyer, C. W. (1981). Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors. Cancer Treatment Reports, 65(Suppl. 2), 39-43.

Osmotic blood-brain barrier disruption : Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors. / Neuwelt, E. A.; Hill, S. A.; Frenkel, E. P.; Diehl, J. T.; Maravilla, K. R.; Vu, L. H.; Clark, W. K.; Rapoport, S. I.; Barnett, P. A.; Lewis, S. E.; Ehle, A. L.; Beyer, C. W.

In: Cancer Treatment Reports, Vol. 65, No. Suppl. 2, 1981, p. 39-43.

Research output: Contribution to journalArticle

Neuwelt, EA, Hill, SA, Frenkel, EP, Diehl, JT, Maravilla, KR, Vu, LH, Clark, WK, Rapoport, SI, Barnett, PA, Lewis, SE, Ehle, AL & Beyer, CW 1981, 'Osmotic blood-brain barrier disruption: Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors', Cancer Treatment Reports, vol. 65, no. Suppl. 2, pp. 39-43.
Neuwelt, E. A. ; Hill, S. A. ; Frenkel, E. P. ; Diehl, J. T. ; Maravilla, K. R. ; Vu, L. H. ; Clark, W. K. ; Rapoport, S. I. ; Barnett, P. A. ; Lewis, S. E. ; Ehle, A. L. ; Beyer, C. W. / Osmotic blood-brain barrier disruption : Pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors. In: Cancer Treatment Reports. 1981 ; Vol. 65, No. Suppl. 2. pp. 39-43.
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AU - Clark, W. K.

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