Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Mitsuo Iida

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the 'left knee' occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalNDT Plus
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2009

Keywords

  • Calcitonin receptor
  • Multi-nucleated giant cell
  • Osteoclast
  • Tumoral calcinosis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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    Yamada, S., Taniguchi, M., Tokumoto, M., Tsuruya, K., & Iida, M. (2009). Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis. NDT Plus, 2(2), 155-157. https://doi.org/10.1093/ndtplus/sfp010