Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Mitsuo Iida

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the 'left knee' occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalNDT Plus
Volume2
Issue number2
DOIs
StatePublished - Apr 2009

Fingerprint

Calcinosis
Osteoclasts
Giant Cells
Calcitonin Receptors
Femur Head
X-Ray Film
Bone Remodeling
Phosphoric Monoester Hydrolases
Renal Dialysis
Hip
Knee
Immunohistochemistry
Calcium
Biopsy
Pain
Therapeutics
tartaric acid

Keywords

  • Calcitonin receptor
  • Multi-nucleated giant cell
  • Osteoclast
  • Tumoral calcinosis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Yamada, S., Taniguchi, M., Tokumoto, M., Tsuruya, K., & Iida, M. (2009). Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis. NDT Plus, 2(2), 155-157. https://doi.org/10.1093/ndtplus/sfp010

Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis. / Yamada, Shunsuke; Taniguchi, Masatomo; Tokumoto, Masanori; Tsuruya, Kazuhiko; Iida, Mitsuo.

In: NDT Plus, Vol. 2, No. 2, 04.2009, p. 155-157.

Research output: Contribution to journalArticle

Yamada, S, Taniguchi, M, Tokumoto, M, Tsuruya, K & Iida, M 2009, 'Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis', NDT Plus, vol. 2, no. 2, pp. 155-157. https://doi.org/10.1093/ndtplus/sfp010
Yamada S, Taniguchi M, Tokumoto M, Tsuruya K, Iida M. Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis. NDT Plus. 2009 Apr;2(2):155-157. https://doi.org/10.1093/ndtplus/sfp010
Yamada, Shunsuke ; Taniguchi, Masatomo ; Tokumoto, Masanori ; Tsuruya, Kazuhiko ; Iida, Mitsuo. / Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis. In: NDT Plus. 2009 ; Vol. 2, No. 2. pp. 155-157.
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