Osteoporosis: Combination therapy for better or worse

N. Maalouf, J. Wehbe, A. Nehme, P. Najem, R. Chidiac, J. Eid, P. Attalah, G. Adib, Ghassan Maalouf

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Osteoporosis is a condition that is associated with an increased susceptibility for fractures. In the past few years, several drugs have become available that can reduce the incidence of fractures in patients with osteoporosis. Since these drugs work through different cellular mechanisms, combining agents of different classes may have an additive or multiplicative effect on fracture risk reduction. Combination treatments that have been evaluated in clinical trials include bisphosphonates with estrogen, raloxifene or PTH/ bisphosphonates and PTH/ estrogen. In general, these trials have shown increases in bone mineral density over that observed with each agent alone. However, whether anti-fracture efficacy is improved, or worsened remains to be established. This article reviews the combination treatments that have been evaluated in clinical trials, with a discussion of the potential benefits and risks that those treatments entail. Integrating safety and cost issues will eventually determine whether those combinations will become the standard of care.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalJournal of Musculoskeletal Neuronal Interactions
Volume3
Issue number2
StatePublished - Jun 1 2003

Keywords

  • Drug therapy combination
  • Osteoporosis
  • Sequential

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine

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  • Cite this

    Maalouf, N., Wehbe, J., Nehme, A., Najem, P., Chidiac, R., Eid, J., Attalah, P., Adib, G., & Maalouf, G. (2003). Osteoporosis: Combination therapy for better or worse. Journal of Musculoskeletal Neuronal Interactions, 3(2), 141-147.