Ototoxicity of low‐ and moderate‐dose cisplatin

S. D. Schaefer, J. D. Post, L. G. Close, C. G. Wright

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

Twenty‐four patients with head and neck neoplasms were prospectively evaluated for cisplatin (DDP)‐induced ototoxicity. Patients were selected from a larger population based on the uniformity of their chemotherapy regimen, renal status, lack of prior or concurrent exposure to ototoxic agents, and availability for repetitive audiometric testing in the same setting. Scanning electron microscopy of the inner ear was performed on four temporal bones. Hearing impairment was found to be dose‐related, irreversible within the confines of the study period, and primarily in the higher frequencies. Vestibular toxicity was rare and well‐documented by our testing methods in only one patient. Based on the results of this study, and a review of animal and human data on DDP ototoxicity, the authors concluded that ototoxic screening should be reserved for patients defined as “at risk” and those patients receiving more than 400 mg of DDP under the conditions stated in this report. Cancer 56: 1934‐1939, 1985.

Original languageEnglish (US)
Pages (from-to)1934-1939
Number of pages6
JournalCancer
Volume56
Issue number8
DOIs
StatePublished - Oct 15 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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