Ototoxicity of neomycin and polymyxin B following middle ear application in the chinchilla and baboon

C. G. Wright, W. L. Meyerhoff, A. R. Halama

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Previous experimental studies have demonstrated structural damage of the organ of Corti and stria vascularis following application of combination antibiotic otic drops to the middle ear. In this investigation the ototoxic effects of neomycin and polymyxin B (two antibiotics often used together in ototopical preparations) were separately evaluated after administration of each agent to the middle ear cavities of chinchillas and baboons. The antibiotics were administered in saline solution at the same concentrations used in Cortisporin Otic Suspension (3.5 mg/ml neomycin base, 10,000 units/ml polymyxin B). In both the rodent and primate, polymyxin B consistently produced greater cochlear damage than did neomycin. In fact, the extent of hair cell loss and strial injury produced by polymyxin B alone was, in many cases, comparable to that previously observed after application of Cortisporin Otic Suspension itself. Hair cell loss in the baboon was markedly less severe than in the chinchilla. It is believed that differences in position and structure of the round window membrane are important factors in the differing levels of ototoxicity observed in the rodent and primate.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalAmerican Journal of Otology
Volume8
Issue number6
StatePublished - 1987

Fingerprint

Framycetin
Chinchilla
Polymyxin B
Papio
Middle Ear
Ear
Neomycin
Alopecia
Anti-Bacterial Agents
Primates
Rodentia
Suspensions
Stria Vascularis
Organ of Corti
Cochlea
Sodium Chloride
Membranes
Wounds and Injuries

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Ototoxicity of neomycin and polymyxin B following middle ear application in the chinchilla and baboon. / Wright, C. G.; Meyerhoff, W. L.; Halama, A. R.

In: American Journal of Otology, Vol. 8, No. 6, 1987, p. 495-499.

Research output: Contribution to journalArticle

Wright, C. G. ; Meyerhoff, W. L. ; Halama, A. R. / Ototoxicity of neomycin and polymyxin B following middle ear application in the chinchilla and baboon. In: American Journal of Otology. 1987 ; Vol. 8, No. 6. pp. 495-499.
@article{319e3c62ba9e4c1ea47343ae9254761f,
title = "Ototoxicity of neomycin and polymyxin B following middle ear application in the chinchilla and baboon",
abstract = "Previous experimental studies have demonstrated structural damage of the organ of Corti and stria vascularis following application of combination antibiotic otic drops to the middle ear. In this investigation the ototoxic effects of neomycin and polymyxin B (two antibiotics often used together in ototopical preparations) were separately evaluated after administration of each agent to the middle ear cavities of chinchillas and baboons. The antibiotics were administered in saline solution at the same concentrations used in Cortisporin Otic Suspension (3.5 mg/ml neomycin base, 10,000 units/ml polymyxin B). In both the rodent and primate, polymyxin B consistently produced greater cochlear damage than did neomycin. In fact, the extent of hair cell loss and strial injury produced by polymyxin B alone was, in many cases, comparable to that previously observed after application of Cortisporin Otic Suspension itself. Hair cell loss in the baboon was markedly less severe than in the chinchilla. It is believed that differences in position and structure of the round window membrane are important factors in the differing levels of ototoxicity observed in the rodent and primate.",
author = "Wright, {C. G.} and Meyerhoff, {W. L.} and Halama, {A. R.}",
year = "1987",
language = "English (US)",
volume = "8",
pages = "495--499",
journal = "Otology and Neurotology",
issn = "1531-7129",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Ototoxicity of neomycin and polymyxin B following middle ear application in the chinchilla and baboon

AU - Wright, C. G.

AU - Meyerhoff, W. L.

AU - Halama, A. R.

PY - 1987

Y1 - 1987

N2 - Previous experimental studies have demonstrated structural damage of the organ of Corti and stria vascularis following application of combination antibiotic otic drops to the middle ear. In this investigation the ototoxic effects of neomycin and polymyxin B (two antibiotics often used together in ototopical preparations) were separately evaluated after administration of each agent to the middle ear cavities of chinchillas and baboons. The antibiotics were administered in saline solution at the same concentrations used in Cortisporin Otic Suspension (3.5 mg/ml neomycin base, 10,000 units/ml polymyxin B). In both the rodent and primate, polymyxin B consistently produced greater cochlear damage than did neomycin. In fact, the extent of hair cell loss and strial injury produced by polymyxin B alone was, in many cases, comparable to that previously observed after application of Cortisporin Otic Suspension itself. Hair cell loss in the baboon was markedly less severe than in the chinchilla. It is believed that differences in position and structure of the round window membrane are important factors in the differing levels of ototoxicity observed in the rodent and primate.

AB - Previous experimental studies have demonstrated structural damage of the organ of Corti and stria vascularis following application of combination antibiotic otic drops to the middle ear. In this investigation the ototoxic effects of neomycin and polymyxin B (two antibiotics often used together in ototopical preparations) were separately evaluated after administration of each agent to the middle ear cavities of chinchillas and baboons. The antibiotics were administered in saline solution at the same concentrations used in Cortisporin Otic Suspension (3.5 mg/ml neomycin base, 10,000 units/ml polymyxin B). In both the rodent and primate, polymyxin B consistently produced greater cochlear damage than did neomycin. In fact, the extent of hair cell loss and strial injury produced by polymyxin B alone was, in many cases, comparable to that previously observed after application of Cortisporin Otic Suspension itself. Hair cell loss in the baboon was markedly less severe than in the chinchilla. It is believed that differences in position and structure of the round window membrane are important factors in the differing levels of ototoxicity observed in the rodent and primate.

UR - http://www.scopus.com/inward/record.url?scp=0023603283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023603283&partnerID=8YFLogxK

M3 - Article

C2 - 2829633

AN - SCOPUS:0023603283

VL - 8

SP - 495

EP - 499

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 6

ER -