Ototoxicity of Vasocidin drops applied to the chinchilla middle ear

O. E. Brown, C. G. Wright, M. Masaki, W. L. Meyerhoff

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Some widely used ototopical preparations are potentially toxic to the middle and inner ear. Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic side effects in the treatment of otorrhea. Vasocidin was introduced into the bullae of nine chinchillas to investigate the effects on the middle and inner ear. The organ of Corti and stria vascularis were found to be entirely normal in 17 of the 18 temporal bones studied. Changes observed in the middle ears at one week included inflammation, hemorrhage, and effusion. Examination of specimens at four weeks revealed resolution of most of the inflammatory changes. The results of this experimental study indicate that Vasocidin causes reversible middle ear inflammation with little or no toxic effect on inner ear structures.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume114
Issue number1
StatePublished - 1988

Fingerprint

Chinchilla
Poisons
Middle Ear
Inner Ear
Sulfacetamide
Stria Vascularis
Organ of Corti
Ophthalmic Solutions
Temporal Bone
Otitis Media
Blister
Hemorrhage
Inflammation
sulfanizolone

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Brown, O. E., Wright, C. G., Masaki, M., & Meyerhoff, W. L. (1988). Ototoxicity of Vasocidin drops applied to the chinchilla middle ear. Archives of Otolaryngology - Head and Neck Surgery, 114(1), 56-59.

Ototoxicity of Vasocidin drops applied to the chinchilla middle ear. / Brown, O. E.; Wright, C. G.; Masaki, M.; Meyerhoff, W. L.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 114, No. 1, 1988, p. 56-59.

Research output: Contribution to journalArticle

Brown, OE, Wright, CG, Masaki, M & Meyerhoff, WL 1988, 'Ototoxicity of Vasocidin drops applied to the chinchilla middle ear', Archives of Otolaryngology - Head and Neck Surgery, vol. 114, no. 1, pp. 56-59.
Brown, O. E. ; Wright, C. G. ; Masaki, M. ; Meyerhoff, W. L. / Ototoxicity of Vasocidin drops applied to the chinchilla middle ear. In: Archives of Otolaryngology - Head and Neck Surgery. 1988 ; Vol. 114, No. 1. pp. 56-59.
@article{83233b90832647f3ad135828533dd1fa,
title = "Ototoxicity of Vasocidin drops applied to the chinchilla middle ear",
abstract = "Some widely used ototopical preparations are potentially toxic to the middle and inner ear. Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic side effects in the treatment of otorrhea. Vasocidin was introduced into the bullae of nine chinchillas to investigate the effects on the middle and inner ear. The organ of Corti and stria vascularis were found to be entirely normal in 17 of the 18 temporal bones studied. Changes observed in the middle ears at one week included inflammation, hemorrhage, and effusion. Examination of specimens at four weeks revealed resolution of most of the inflammatory changes. The results of this experimental study indicate that Vasocidin causes reversible middle ear inflammation with little or no toxic effect on inner ear structures.",
author = "Brown, {O. E.} and Wright, {C. G.} and M. Masaki and Meyerhoff, {W. L.}",
year = "1988",
language = "English (US)",
volume = "114",
pages = "56--59",
journal = "JAMA Otolaryngology - Head and Neck Surgery",
issn = "2168-6181",
publisher = "American Medical Association",
number = "1",

}

TY - JOUR

T1 - Ototoxicity of Vasocidin drops applied to the chinchilla middle ear

AU - Brown, O. E.

AU - Wright, C. G.

AU - Masaki, M.

AU - Meyerhoff, W. L.

PY - 1988

Y1 - 1988

N2 - Some widely used ototopical preparations are potentially toxic to the middle and inner ear. Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic side effects in the treatment of otorrhea. Vasocidin was introduced into the bullae of nine chinchillas to investigate the effects on the middle and inner ear. The organ of Corti and stria vascularis were found to be entirely normal in 17 of the 18 temporal bones studied. Changes observed in the middle ears at one week included inflammation, hemorrhage, and effusion. Examination of specimens at four weeks revealed resolution of most of the inflammatory changes. The results of this experimental study indicate that Vasocidin causes reversible middle ear inflammation with little or no toxic effect on inner ear structures.

AB - Some widely used ototopical preparations are potentially toxic to the middle and inner ear. Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic side effects in the treatment of otorrhea. Vasocidin was introduced into the bullae of nine chinchillas to investigate the effects on the middle and inner ear. The organ of Corti and stria vascularis were found to be entirely normal in 17 of the 18 temporal bones studied. Changes observed in the middle ears at one week included inflammation, hemorrhage, and effusion. Examination of specimens at four weeks revealed resolution of most of the inflammatory changes. The results of this experimental study indicate that Vasocidin causes reversible middle ear inflammation with little or no toxic effect on inner ear structures.

UR - http://www.scopus.com/inward/record.url?scp=0023931418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023931418&partnerID=8YFLogxK

M3 - Article

C2 - 3334819

AN - SCOPUS:0023931418

VL - 114

SP - 56

EP - 59

JO - JAMA Otolaryngology - Head and Neck Surgery

JF - JAMA Otolaryngology - Head and Neck Surgery

SN - 2168-6181

IS - 1

ER -