Outcome of diffuse large B-cell lymphoma in the united states has improved over time but racial disparities remain: Review of SEER data

Rami S. Komrokji, Najla H. Al Ali, M. S. Beg, Malek M. Safa, Dana Rollison, Mohamed Kharfan-Dabaja, Celeste Bello, Jennifer Cultrera, Lubomir Sokol, Javier Pinilla-Ibarz, Eduardo M. Sotomayor

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: Diffuse large B-cell non-Hodgkin lymphoma (DLBCL) outcome in the United States has not been reported outside the context of clinical trials. Patients and Methods: We reviewed the Surveillance, Epidemiology, and End Results (SEER) registry and compared survival trends among DLBCL patients from 1973 to 2004. Results: We identified 59,728 patients (mean age, 63 years; 54.4% men, 86.7% white) and had staging information for 57%, including 30% early-stage (I/II) and 27% advanced-stage (III/IV). Median overall survival (OS) from 1973 to 1979, 1980 to 1989,1990 to 1999, and 2000 to 2004 was 15, 18, 20, and 47 months, respectively (P <.005). For the period from 2000 to 2004, 4-year OS was 46%. Outcome was better in white patients than in black (47 months versus 29 months) (P =.001). Median OS for patients younger than 60 years old was not reached versus 23 months for patients older than 60 years. Conclusion: The outcome of DLBCL in the United States has improved significantly in the era of monoclonal antibodies; however, racial disparities remain.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue number3
DOIs
StatePublished - Jun 2011

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Keywords

  • Diffuse large B-cell lymphoma
  • Non-Hodgkin lymphoma
  • SEER

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Komrokji, R. S., Al Ali, N. H., Beg, M. S., Safa, M. M., Rollison, D., Kharfan-Dabaja, M., Bello, C., Cultrera, J., Sokol, L., Pinilla-Ibarz, J., & Sotomayor, E. M. (2011). Outcome of diffuse large B-cell lymphoma in the united states has improved over time but racial disparities remain: Review of SEER data. Clinical Lymphoma, Myeloma and Leukemia, 11(3), 257-260. https://doi.org/10.1016/j.clml.2011.03.012