Outcome of noninvasive ventilation in children with neuromuscular disease

H. K. Young, A. Lowe, D. A. Fitzgerald, C. Seton, K. A. Waters, E. Kenny, L. S. Hynan, S. T. Iannaccone, K. N. North, M. M. Ryan

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

OBJECTIVE: To assess the effect of institution of noninvasive ventilation (NIV) on clinical outcome and quality of life (QOL) in a cohort of children with severe neuromuscular disorders. METHODS: We reviewed records and obtained clinical data from the year prior to commencing NIV and annually thereafter. Data obtained included diagnosis, patient symptoms, mortality, NIV adverse effects, pulmonary function tests, polysomnographic data, length of hospitalizations, and health care costs. Patients and parents completed questionnaires assessing QOL with NIV and recalling QOL before NIV. RESULTS: Fourteen of 17 (82%) suitable patients were enrolled. Follow-up ranged from 6 to 84 months (median 30). Symptoms of daytime sleepiness (p = 0.003) and headache (p = 0.046) improved after initiation of NIV. Sleep quality assessed by polysomnography also improved. Hospitalization rates (p = 0.002) and health care costs (p = 0.003) decreased. QOL remained stable after NIV, despite disease progression. CONCLUSION: Treatment of respiratory failure, in children with neuromuscular disease, with noninvasive ventilation results in a reduction in symptoms, hospitalizations, and health care costs without adverse effects on quality of life.

Original languageEnglish (US)
Pages (from-to)198-201
Number of pages4
JournalNeurology
Volume68
Issue number3
DOIs
StatePublished - Jan 2007

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Noninvasive Ventilation
Neuromuscular Diseases
Quality of Life
Health Care Costs
Hospitalization
Polysomnography
Respiratory Function Tests
Treatment Failure
Respiratory Insufficiency
Headache
Disease Progression
Sleep
Parents
Mortality

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Young, H. K., Lowe, A., Fitzgerald, D. A., Seton, C., Waters, K. A., Kenny, E., ... Ryan, M. M. (2007). Outcome of noninvasive ventilation in children with neuromuscular disease. Neurology, 68(3), 198-201. https://doi.org/10.1212/01.wnl.0000251299.54608.13

Outcome of noninvasive ventilation in children with neuromuscular disease. / Young, H. K.; Lowe, A.; Fitzgerald, D. A.; Seton, C.; Waters, K. A.; Kenny, E.; Hynan, L. S.; Iannaccone, S. T.; North, K. N.; Ryan, M. M.

In: Neurology, Vol. 68, No. 3, 01.2007, p. 198-201.

Research output: Contribution to journalArticle

Young, HK, Lowe, A, Fitzgerald, DA, Seton, C, Waters, KA, Kenny, E, Hynan, LS, Iannaccone, ST, North, KN & Ryan, MM 2007, 'Outcome of noninvasive ventilation in children with neuromuscular disease', Neurology, vol. 68, no. 3, pp. 198-201. https://doi.org/10.1212/01.wnl.0000251299.54608.13
Young HK, Lowe A, Fitzgerald DA, Seton C, Waters KA, Kenny E et al. Outcome of noninvasive ventilation in children with neuromuscular disease. Neurology. 2007 Jan;68(3):198-201. https://doi.org/10.1212/01.wnl.0000251299.54608.13
Young, H. K. ; Lowe, A. ; Fitzgerald, D. A. ; Seton, C. ; Waters, K. A. ; Kenny, E. ; Hynan, L. S. ; Iannaccone, S. T. ; North, K. N. ; Ryan, M. M. / Outcome of noninvasive ventilation in children with neuromuscular disease. In: Neurology. 2007 ; Vol. 68, No. 3. pp. 198-201.
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