TY - JOUR
T1 - Outcomes and prognostic factors in patients with a single lymph node metastasis at time of radical cystectomy
AU - Rink, Michael
AU - Hansen, Jens
AU - Cha, Eugene K.
AU - Green, David A.
AU - Babjuk, Marko
AU - Svatek, Robert S.
AU - Xylinas, Evanguelos
AU - Tagawa, Scott T.
AU - Faison, Talia
AU - Novara, Giacomo
AU - Karakiewicz, Pierre I.
AU - Daneshmand, Siamak
AU - Lotan, Yair
AU - Kassouf, Wassim
AU - Fritsche, Hans Martin
AU - Pycha, Armin
AU - Comploj, Evi
AU - Tilki, Derya
AU - Bastian, Patrick J.
AU - Chun, Felix K.
AU - Dahlem, Roland
AU - Scherr, Douglas S.
AU - Shariat, Shahrokh F.
PY - 2013/1
Y1 - 2013/1
N2 - Objectives: To identify clinicopathological factors that predict outcomes in patients with a single lymph node (LN) metastasis (pN1) treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). LN metastasis is an established predictor of clinical outcomes in patients. While most patients with large LN burden experience disease recurrence, lymphadenectomy can be curative in patients with pN1 disease. Patients and Methods: We analysed 381 patients with pN1 UCB from a multi-institutional cohort of 4335 patients with UCB treated with RC and lymphadenectomy without preoperative chemo- or radiotherapy. Subgroup analyses were performed for patients with ≥9 LNs removed and according to adjuvant chemotherapy administration (n = 215). Results: The median (interquartile range, IQR) LN number was 15 (19) and the median (IQR) LN density was 6.7 (7.5)%. Within a median follow-up of 41 months, the mean (+/- sd) 2- and 5-year cancer-specific survival (CSS) rates were 55 (3)% and 46 (3)%, respectively. On multivariable analysis that adjusted for the effects of standard clinicopathological features, female gender (hazard ratio [HR] 1.48, P = 0.023), higher tumour stage (HR 1.68, P = 0.007), positive soft tissue surgical margin (STSM; HR 2.06, P = 0.004), higher LN density (HR 2.99, P = 0.025) and absence of adjuvant chemotherapy (HR 0.70, P = 0.026) were independently associated with CSS. In subgroup analyses of patients with ≥9 LNs removed, tumour stage and STSM status remained independent predictors for CSS (P = 0.009 and P < 0.001, respectively). Conclusions: About half of the patients with pN1 UCB died from UCB within 5 years of RC. Pathological stage and STSM status are strong predictors for outcomes. Accurate prediction of the individual risk of CSS may help risk stratifying pN1 UCB in order to help improve clinical-decision making. Patients with pN1 UCB presenting with additional unfavourable risk factors need a closer follow-up scheduling and might receive adjuvant therapy.
AB - Objectives: To identify clinicopathological factors that predict outcomes in patients with a single lymph node (LN) metastasis (pN1) treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). LN metastasis is an established predictor of clinical outcomes in patients. While most patients with large LN burden experience disease recurrence, lymphadenectomy can be curative in patients with pN1 disease. Patients and Methods: We analysed 381 patients with pN1 UCB from a multi-institutional cohort of 4335 patients with UCB treated with RC and lymphadenectomy without preoperative chemo- or radiotherapy. Subgroup analyses were performed for patients with ≥9 LNs removed and according to adjuvant chemotherapy administration (n = 215). Results: The median (interquartile range, IQR) LN number was 15 (19) and the median (IQR) LN density was 6.7 (7.5)%. Within a median follow-up of 41 months, the mean (+/- sd) 2- and 5-year cancer-specific survival (CSS) rates were 55 (3)% and 46 (3)%, respectively. On multivariable analysis that adjusted for the effects of standard clinicopathological features, female gender (hazard ratio [HR] 1.48, P = 0.023), higher tumour stage (HR 1.68, P = 0.007), positive soft tissue surgical margin (STSM; HR 2.06, P = 0.004), higher LN density (HR 2.99, P = 0.025) and absence of adjuvant chemotherapy (HR 0.70, P = 0.026) were independently associated with CSS. In subgroup analyses of patients with ≥9 LNs removed, tumour stage and STSM status remained independent predictors for CSS (P = 0.009 and P < 0.001, respectively). Conclusions: About half of the patients with pN1 UCB died from UCB within 5 years of RC. Pathological stage and STSM status are strong predictors for outcomes. Accurate prediction of the individual risk of CSS may help risk stratifying pN1 UCB in order to help improve clinical-decision making. Patients with pN1 UCB presenting with additional unfavourable risk factors need a closer follow-up scheduling and might receive adjuvant therapy.
KW - adjuvant chemotherapy
KW - bladder cancer
KW - lymph node metastasis
KW - nomogram
KW - radical cystectomy
KW - survival
KW - urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84871608722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871608722&partnerID=8YFLogxK
U2 - 10.1111/j.1464-410X.2012.11356.x
DO - 10.1111/j.1464-410X.2012.11356.x
M3 - Article
C2 - 22809039
AN - SCOPUS:84871608722
SN - 1464-4096
VL - 111
SP - 74
EP - 84
JO - BJU international
JF - BJU international
IS - 1
ER -